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Method for sterilization in vivo and improving repair performance of biological cartilage tissue

A cartilage repair and performance technology, applied in the field of medical scaffolds, can solve the problems of insufficient mechanical strength, excessive degradation rate, high cost of collagen, etc., and achieve the effects of improving degradation resistance, improving mechanical properties, and accelerating metabolism

Inactive Publication Date: 2020-05-19
SHANDONG JIANZHU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages: fast degradation rate, insufficient mechanical strength, high cost of obtaining high-purity collagen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0015] Prepare an aqueous solution (1%) of PVA17-88. ;Take 100mg PLGA (LA / GA=50 / 50, molecular weight 55,000), dissolve it in 1ml of chloroform: take another 10mgAgCl powder precipitate, add it to this chloroform, add 10uL triethylamine, let it stand for 10 minutes, and observe whether Dissolve, if not dissolved, continue to add 5uL. Under constant stirring at 1000rpm, take the above chloroform solution and add it dropwise into the aqueous solution containing PVA17-88. The volume of the aqueous solution is 25 times the volume of chloroform. After adding, homogenize at high speed (7000rpm) for 15s. Transfer to a fume hood and continue stirring (600 rpm) for 2 minutes. An equal volume of distilled water was added, and stirring was continued for 4 hours. After the chloroform is volatilized, the solution is centrifuged at high speed (15,000 rpm, temperature 4°C) for 1 min, dispersed with an appropriate amount of distilled water, and freeze-dried. The pore size of the porous stru...

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Abstract

The invention relates to the field of medical scaffolds, and relates to a fibrin material beneficial to cartilage repair. The fibrin material is a fibrinogen scaffold gelated under thrombin, and PLGAin the scaffold can carry Ag ions for human body sterilization, and can be degraded. High concentration of fibrinogen improves the mechanical properties, and improves the degradation resistance of thescaffold material. Due to the existence of porous, the speed of material exchange and biological signal exchange is accelerated. The exchange rate of nutrients increases when the nutrients pass through the pores in the human body. When the porous fibrin cartilage repair material is transplanted into the body, the fibrin cartilage repair material has good compatibility with human bone tissue and good binding ability, and the regeneration of cartilage is realized. According to the present invention, in situ cartilage induced regeneration can be achieved by the method, the object of in situ regeneration and repair is achieved, and the method has good clinical application prospects. The current phenomenon that the injury of cartilage tissue can not be well repaired by collagen clinically is overcome.

Description

technical field [0001] The invention relates to the field of medical stents, and relates to a method for sterilizing bacteria in vivo and improving cartilage tissue repair performance. Background technique [0002] The joint surface is covered by cartilage to become articular cartilage. Under normal circumstances, cartilage has a good protective effect on the joints, and the friction is very low, allowing the joints to perform various bending and straightening activities normally. Such joints are normal , there will be no discomfort, pain, swelling or even limited bending. However, if the cartilage is damaged due to some reasons, the cartilage will swell, the surface will be fluffed, eroded, cracked, broken, and even fall off. In severe cases, the bone under the cartilage will be exposed. This kind of cartilage injury is difficult to treat. Cartilage has no blood vessels, and there are no nerves in it. Cartilage damage may be asymptomatic at the beginning, but as the cartil...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/56A61L27/50A61L27/54A61L27/12A61L27/18A61L27/16A61L27/02
CPCA61L27/025A61L27/12A61L27/16A61L27/18A61L27/225A61L27/227A61L27/50A61L27/54A61L27/56A61L2300/104A61L2300/404A61L2430/06C08L89/00C08L67/04C08L29/04
Inventor 徐淑波张世超孙化鑫孙海波刘建营王瀚林孙星
Owner SHANDONG JIANZHU UNIV
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