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A kind of bionic osteochondral complex and its preparation method

A bionic bone and composite technology, applied in prostheses, tissue regeneration, bone implants, etc., can solve problems such as poor repair effect, and achieve the effect of increasing the contact surface, avoiding cell loss, and firmly fixing

Active Publication Date: 2021-05-14
SHANGHAI BIO LU BIOMATERIALS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The object of the present invention is to provide a bionic osteochondral complex and a preparation method thereof, so as to solve the problem of poor repair effect of the scaffold required for cartilage repair in the prior art

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  • A kind of bionic osteochondral complex and its preparation method
  • A kind of bionic osteochondral complex and its preparation method
  • A kind of bionic osteochondral complex and its preparation method

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Embodiment Construction

[0033]The biomimetic osteochondral complex proposed by the present invention and its preparation method will be further described in detail below with reference to the accompanying drawings and specific examples. Advantages and features of the present invention will be apparent from the following description and claims. It should be noted that all the drawings are in a very simplified form and use imprecise scales, and are only used to facilitate and clearly assist the purpose of illustrating the embodiments of the present invention.

[0034] The inventor has carried out detailed and in-depth research on the structure of articular cartilage, and found that articular cartilage is rich in collagen, proteoglycan and chondrocytes, and the connection between articular cartilage and subchondral bone is a complex structure, such as figure 1 As shown, the connecting structure mainly includes mature cartilage (NCC), calcified cartilage (CC), tide line (Tidemark, Tm), subchondral bone p...

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Abstract

The invention provides a bionic osteochondral complex and a preparation method thereof. The bionic osteochondral complex includes a cartilage layer, a barrier layer and a subchondral bone layer, and the two sides of the barrier layer are respectively connected to the subchondral bone layer and the subchondral bone layer. The cartilage layer is connected. The bionic osteochondral complex provided by the present invention can be implanted in human cartilage damage sites, and the cartilage, subchondral barrier layer and subchondral bone can be repaired in an integrated way, and the formation can not only induce the migration of endogenous cells but also play a barrier function biomimetic osteochondral prosthesis.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a bionic osteochondral complex and a preparation method thereof. Background technique [0002] Cartilage damage may lead to the occurrence of osteoarthritis, and the latest research has found that subchondral bone damage also has an important impact on the occurrence of osteoarthritis. It is clinically believed that repairing cartilage can effectively delay the occurrence of osteoarthritis, but articular cartilage damage is often accompanied by subchondral bone damage. Existing treatment methods only focus on cartilage repair, and the bone structure under the repaired cartilage is often unstable. [0003] Microfracture repair of cartilage is a commonly used clinical cartilage repair method. It drills holes in the subchondral bone at the defect site and guides bone marrow stem cells to repair the cartilage. The cartilage formed is often fibrocartilage. According to the follow-up resu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/10A61L27/12A61L27/50A61L27/56A61F2/28A61F2/30
CPCA61F2/28A61F2/30756A61F2/30767A61F2002/2835A61F2002/3006A61L27/10A61L27/12A61L27/24A61L27/50A61L27/56A61L2430/06
Inventor 卢建熙卢霄王臻高旭姚宸维
Owner SHANGHAI BIO LU BIOMATERIALS
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