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A kind of preparation method and application of composite hyaluronic acid collagen hydrogel

A technology for compounding hyaluronic acid glue and collagen, which is applied in the field of medical materials and can solve problems affecting the properties of solutions

Active Publication Date: 2020-06-16
ZHEJIANG JINGJIA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large amount of data and test results show that the composite solution will produce a large amount of white flocculent polyelectrolyte precipitates after simply dissolving the two, which will affect the properties of the solution.

Method used

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  • A kind of preparation method and application of composite hyaluronic acid collagen hydrogel
  • A kind of preparation method and application of composite hyaluronic acid collagen hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077]Dissolve hyaluronic acid (5.0g) in purified water (95.0g), stir to make it dissolve completely, so that the concentration of hyaluronic acid in the mixed solution is 5wt%;

[0078] The molecular weight of hyaluronic acid is 300,000-3,000,000 Da;

[0079] Dilute the collagen stock solution with purified water to a concentration of 2wt%, and stir evenly;

[0080] Mix the above two solutions in equal proportions (mass ratio 1:1), add carbonate buffer system (0.2M), and stir evenly until the precipitation disappears for later use, thereby obtaining the composite hyaluronic acid collagen hydrogel of the present invention, wherein, figure 1 It shows the white flocculent polyelectrolyte precipitate (visual inspection) produced after complexing of the two components without adjustment of the carbonate buffer system.

[0081] Such as figure 2 As shown, in the composite hyaluronic acid collagen hydrogel of the present invention, the content of polyelectrolyte precipitate is <0....

Embodiment 2

[0083] Dissolve hyaluronic acid (2.0g) in purified water (98.0g), stir to make it dissolve completely, so that the concentration of hyaluronic acid in the mixed solution is 2wt%;

[0084] The molecular weight of hyaluronic acid is 300,000-3,000,000 Da;

[0085] Dilute the collagen stock solution with purified water to a concentration of 1 wt%, and stir evenly;

[0086] Mix the above two solutions in equal proportions (mass ratio 1:1), add carbonate buffer system (0.1M), and stir evenly until the precipitation disappears for later use, thereby obtaining the composite hyaluronic acid collagen hydrogel of the present invention, wherein, figure 1 It shows the white flocculent polyelectrolyte precipitate (visual inspection) produced after complexing of the two components without adjustment of the carbonate buffer system.

[0087] Such as figure 2 As shown, in the composite hyaluronic acid collagen hydrogel of the present invention, the content of polyelectrolyte precipitate is <...

Embodiment 3

[0089] Dissolve hyaluronic acid (0.5g) in purified water (99.5g), stir to make it dissolve completely, so that the concentration of hyaluronic acid in the mixed solution is 0.5wt%);

[0090] The molecular weight of hyaluronic acid is 300,000-3,000,000 Da;

[0091] Dilute the collagen stock solution with purified water to a concentration of 0.5wt%) and stir evenly;

[0092] Mix the above two solutions in equal proportions (mass ratio 1:1), add carbonate buffer system (0.05M), and stir evenly until the precipitation disappears for later use, thereby obtaining the composite hyaluronic acid collagen hydrogel of the present invention, wherein, figure 1 It shows the white flocculent polyelectrolyte precipitate (visual inspection) produced after complexing of the two components without adjustment of the carbonate buffer system.

[0093] Such as figure 2 As shown, in the composite hyaluronic acid collagen hydrogel of the present invention, the content of polyelectrolyte precipitate...

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Abstract

The invention provides a preparing method and application of compound hyaluronic acid collagen hydrogel. Particularly, on the condition that a crosslinking material is not contained, hyaluronic acid and collagen are mixed according to a certain proportion, hydrogel can be obtained and has an extremely low content (<0.05wt%) of polyelectrolyte sediment. Moreover, in the obtained hydrogel, the function of hyaluronic acid hydrogel of moisturizing and lubricating the skin can be improved, the function of collagen of guiding tissue repair can be exerted at the same time, larger advantages are shown on the development of medical beauty products, and the compound hyaluronic acid collagen hydrogel can be applied to multiple fields of food, medicine, tissue engineering, cosmetics and the like.

Description

technical field [0001] The invention relates to a medical material containing hydrogel, in particular to a preparation method and application of a composite hyaluronic acid collagen hydrogel. Background technique [0002] Collagen is a substance that supports the skin, while hyaluronic acid can keep the skin smooth and moist. Therefore, the development of medical cosmetic products after combining the two has broad application prospects. However, a large amount of data and test results show that a large amount of white flocculent polyelectrolyte precipitates will be produced in the composite solution after simply dissolving the two, which will affect the properties of the solution. [0003] Therefore, there is an urgent need to develop a method for preparing a composite hyaluronic acid collagen hydrogel that can remove polyelectrolyte precipitates and maintain solution uniformity. Contents of the invention [0004] The object of the present invention is to provide a method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L89/00C08J3/075A61L31/04A61L31/14
CPCA61L31/041A61L31/145C08J3/075C08J2305/08C08J2389/00C08J2405/08C08J2489/00C08L5/08C08L89/00
Inventor 尹烁陆凌峰向小明胡正洋吕强松陈春会李好雨叶东王晔尘孙海胜陈俊
Owner ZHEJIANG JINGJIA MEDICAL TECH CO LTD