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Embryo transfer glue and preparation method thereof

A technology of embryo transfer and saline solution, which is applied in the direction of biochemical equipment and methods, embryonic cells, veterinary instruments, etc., can solve the problems of animal-derived pathogens and toxins, safety issues of assisted reproductive technology, etc., and achieve the elimination of animal-derived The possibility of pathogens and toxins, the effect of increasing effective communication and adhesion, and reducing the rate of miscarriage

Inactive Publication Date: 2017-10-17
瑞柏生物(中国)股份有限公司
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AI Technical Summary

Problems solved by technology

Conventional hyaluronic acid is mainly derived from animal tissues, such as rooster combs, etc., and there is a risk of potential animal-derived pathogens and toxins, which brings safety issues to assisted reproductive technology

Method used

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Embodiment Construction

[0026] The present invention will be further described below in combination with specific implementation methods.

[0027] Embryo transplantation glue according to the present invention adopts recombinant hyaluronic acid, cell clone stimulating factor, and human chorionic gonadotropin according to the concentration of 0.1-0.8 μg / ml, 1-20ng / ml, and 5-500 units / ml respectively Prepared by dissolving in saline solution containing antibiotics and indicators.

[0028] The antibiotics are gentamicin and streptomycin sulfate, wherein the concentration of gentamicin is 5-11 μg / ml and the concentration of streptomycin sulfate is 10-50 μg / ml.

[0029] The indicator is phenol red with a concentration of 9-10 μg / ml.

[0030] The saline solution is a compound culture solution using sodium bicarbonate as a buffer, based on sodium, potassium, magnesium, and calcium ions, and using glucose, sodium pyruvate, sodium lactate, amino acids, and albumin as energy substances; wherein: Sodium chlor...

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Abstract

The invention relates to embryo transfer glue and a preparation method thereof and belongs to the technical field of human assisted reproductive technology. The embryo transfer glue is prepared by dissolving recombinant hyaluronic acid, cell clone stimulating factors and human chorionic gonadotropin into a salt culture solution containing antibiotics and an indicator according to the concentration of 0.1-0.8 microgram / ml, 1-20 nanogram / ml and 5-500 unit / ml. The embryo transfer glue has the advantages that endometrium growth is promoted, and effective communication and adhesive ability between an embryo and the endometrium are increased to increase the implantation rate of the embryo and lower abortion rate by adding the recombinant hyaluronic acid, the cell clone stimulating factors and the human chorionic gonadotropin; the embryo transfer glue is a non-animal-origin recombinant bioengineering high-tech product, the possibility of animal-origin pathogens and toxins is eliminated effectively, and the safety of assisted reproduction can be increased greatly.

Description

technical field [0001] The invention relates to an embryo transfer glue and a preparation method thereof, belonging to the technical field of human assisted reproduction. Background technique [0002] Embryo transfer, also known as fertilized egg transfer, refers to the technology of transplanting early embryos in the mother's body, or embryos obtained through in vitro fertilization and other methods, into other mothers with the same physiological state, so that they can continue to develop into new individuals. In the prior art, the implantation rate of embryo transfer is low and the miscarriage rate is high. [0003] Hyaluronic acid (Hyaluronidase) is an acidic mucopolysaccharide. Its unique molecular structure and physical and chemical properties show a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating proteins, water and electrolytes Diffusion and operation, promote wound h...

Claims

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Application Information

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IPC IPC(8): C12N5/073A61D19/04
CPCA61D19/04C12N5/0604C12N2501/22C12N2501/31C12N2501/905
Inventor 冯怀亮
Owner 瑞柏生物(中国)股份有限公司
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