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Application of PLPP4 ((phospholipid phosphatase 4) as diagnosis, treatment and prognosis target for NSCLC (non-small-cell lung carcinoma)

A non-small cell lung cancer, PLPP4 technology, applied in gene therapy, medical preparations containing active ingredients, microbial measurement/testing, etc., can solve the immature assessment of NSCLC prognosis and cannot fully reflect the clinical prognosis of patients with non-small cell lung cancer Features and other issues

Active Publication Date: 2017-11-07
江门市中心医院
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Problems solved by technology

[0004] So far, NSCLC prognosis assessment based on abnormal gene expression is still immature. On the one hand, genotyping methods based on gene expression differences cannot fully reflect the clinical prognostic characteristics of patients with non-small cell lung cancer; on the other hand, Among the factors affecting the survival and prognosis of patients with non-small cell lung cancer, in addition to the progress of the malignant tumor itself, it is also mixed with various influences of the patient's body itself

Method used

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  • Application of PLPP4 ((phospholipid phosphatase 4) as diagnosis, treatment and prognosis target for NSCLC (non-small-cell lung carcinoma)
  • Application of PLPP4 ((phospholipid phosphatase 4) as diagnosis, treatment and prognosis target for NSCLC (non-small-cell lung carcinoma)
  • Application of PLPP4 ((phospholipid phosphatase 4) as diagnosis, treatment and prognosis target for NSCLC (non-small-cell lung carcinoma)

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Embodiment Construction

[0042] Application of the reagent for quantitatively detecting the copy number of gene PLPP4 and / or the expression level of gene PLPP4 in the preparation of detection and / or prognosis reagents for non-small cell lung cancer.

[0043] A non-small cell lung cancer detection kit contains reagents capable of quantitatively detecting the copy number of gene PLPP4 and / or the expression level of gene PLPP4.

[0044] As a preference of the above non-small cell lung cancer detection kit, the kit contains primers for quantitatively detecting the transcription level of the gene PLPP4.

[0045] As a preferred option of the above-mentioned non-small cell lung cancer detection kit, the sequences of the primers are as follows:

[0046] Upstream primer: 5'-TTTGGATCCGTTCCAGAGAG-3';

[0047]Downstream primer: 5'-CAGGGGTGTGAGGAAAGAAA-3'.

[0048] A prognostic kit for non-small cell lung cancer, the kit contains reagents capable of quantitatively detecting the copy number of the gene PLPP4 and / ...

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Abstract

The invention discloses an application of PLPP4 ((phospholipid phosphatase 4) as a diagnosis, treatment and prognosis target for NSCLC (non-small-cell lung carcinoma). High expression of PLPP4 in tumor tissue and cell lines of NSCLC is discovered, high expression of PLPP4 in lung malignant tumor tissue is related to low clinical pathological grades as well as short overall survival time and progression-free survival time of a patient, in-vitro NSCLC cell proliferation and in-vivo tumorigenesis can be affected by silencing PLPP4, and all the information indicates that PLPP4 can serve as the diagnosis, treatment and prognosis target for NSCLC. Primers performing fluorescent quantitative detection on PLPP4 are taken as reagents for diagnosis and prognosis of NSCLC, and LNA modified sisiRNA capable of specifically silencing PLPP4 is taken as a treatment medicine for NSCLC.

Description

technical field [0001] The invention belongs to a new application of PLPP4, and specifically relates to the application of PLPP4 as a target for diagnosis, treatment and prognosis of non-small cell lung cancer. Background technique [0002] Lung cancer (Lung cancer) is the tumor with the highest incidence and mortality in the world. In 2012, there were about 1.8 million new cases of lung cancer in the world, accounting for 13% of all tumor cases; the male incidence rate was 52.4 cases per 100,000 people, and the death rate The rate was 32.0 cases / 100,000, the female incidence rate was 15.4 cases / 100,000, and the fatality rate was 12.1 cases / 100,000. Lung cancer is also the malignant tumor with the highest incidence and mortality rate in China. In 2015, the total incidence rate in my country was 34.4 cases / 100,000 people, and the fatality rate was 27.5 cases / 100,000 people, both of which were higher than the world average; and many studies have shown that my country The incid...

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Application Information

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IPC IPC(8): C12Q1/68A61K45/00A61K48/00A61K31/713A61P35/00
CPCA61K31/713A61K45/00C12Q1/6886C12Q2600/118C12Q2600/178
Inventor 张鑫
Owner 江门市中心医院
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