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Hydroxyapatite with enamel-like structure and preparation method and application of hydroxyapatite

A technology of hydroxyapatite and tooth enamel, applied in dental preparations, chemical instruments and methods, dentistry, etc., can solve the problems that the repair layer cannot obtain mechanical properties, the repair layer has no structure and orientation, etc.

Active Publication Date: 2017-11-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the repair layer obtained in this way often does not have the same structure and orientation as the original enamel, so the repair layer cannot obtain similar mechanical properties to the enamel.

Method used

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  • Hydroxyapatite with enamel-like structure and preparation method and application of hydroxyapatite
  • Hydroxyapatite with enamel-like structure and preparation method and application of hydroxyapatite
  • Hydroxyapatite with enamel-like structure and preparation method and application of hydroxyapatite

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Effect test

Embodiment 1

[0035] Calcium chloride dihydrate is dissolved in ethanol to obtain a 17mmol / L calcium chloride solution, as solution A; concentrated phosphoric acid and triethylamine (TEA) are dissolved in ethanol to obtain a phosphoric acid concentration of 40mmol / L and a TEA concentration of 1300mmol / L solution B. Mix solution A and solution B at a volume ratio of 4:1 and let it stand for 30 minutes to obtain an ethanol dispersion of calcium phosphate polymerized ions as solution C.

[0036] Centrifuge solution C at a high speed (20000rpm, 5min) and redisperse it in an equal volume of ethanol, then use a dropper to drop 3 drops on the surface of the enamel sample to be repaired and dry it to obtain a layer of amorphous growth on the surface of the enamel. Calcium Phosphate (ACP) repair layer. Afterwards, the enamel sample to be repaired was soaked in the phase change solution. After about one day, the amorphous calcium phosphate repair layer phase changed into enamel-like structure hydrox...

Embodiment 2

[0043] Dissolve calcium chloride dihydrate in ethanol to obtain a 25mmol / L calcium chloride solution as solution A; dissolve concentrated phosphoric acid and TEA in ethanol to obtain a solution with a phosphoric acid concentration of 60mmol / L and a TEA concentration of 1950mmol / L b. Mix solution A and solution B at a volume ratio of 4:1 and let it stand for 40 minutes to obtain an ethanol dispersion of calcium phosphate polymerized ions as solution C.

[0044] Centrifuge solution C at high speed (10000rpm, 5min) and redisperse it in an equal volume of ethanol, then use a dropper to drop 3 drops on the surface of the enamel sample to be repaired and dry it to obtain a layer of amorphous growth on the surface of the enamel. Calcium Phosphate (ACP) repair layer. After that, the enamel sample to be repaired was soaked in the phase change solution, and the amorphous calcium phosphate repair layer phase changed into hydroxyapatite with an enamel-like structure after about one day, ...

Embodiment 3

[0047] Dissolve calcium chloride dihydrate in ethanol to obtain a 30mmol / L calcium chloride solution as solution A; dissolve concentrated phosphoric acid and TEA in ethanol to obtain a solution with a phosphoric acid concentration of 70mmol / L and a TEA concentration of 2300mmol / L b. Mix solution A and solution B at a volume ratio of 4:1 and let it stand for 30 minutes to obtain an ethanol dispersion of calcium phosphate polymerized ions as solution C.

[0048] Centrifuge solution C at high speed (8000rpm, 5min) and redisperse it in an equal volume of ethanol, then use a dropper to drop 3 drops on the surface of the enamel sample to be repaired and dry it to obtain a layer of amorphous growth on the surface of the enamel. Calcium Phosphate (ACP) repair layer. Afterwards, the enamel sample to be repaired was soaked in the phase change solution. After about one day, the amorphous calcium phosphate repair layer phase changed into hydroxyapatite with an enamel-like structure, and ...

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Abstract

The invention provides hydroxyapatite with an enamel-like structure and a preparation method of the hydroxyapatite. A calcium phosphate polymerization ion is taken as a precursor, and the hydroxyapatite with the enamel-like structure is prepared on the enamel surface through the precursor. The hydroxyapatite with the enamel-like structure serves as a repair material for enamel; the enamel structure in superficial caries can be fast repaired; the orderness and the orientation of the repaired structure are completely consistent with those of to-be-repaired enamel; and the mechanical property of the repaired enamel is consistent with that of natural enamel.

Description

technical field [0001] The invention relates to tooth enamel restoration materials, in particular to a preparation method and application of hydroxyapatite with an enamel-like structure. Background technique [0002] Dental caries, also known as tooth decay, is one of the most prevalent chronic diseases in human society, and may even accompany individuals throughout their lives. This is a disease in which oral bacteria ferment carbohydrates to produce acidic substances, which corrode the teeth and cause local damage. It is also the main cause of oral pain and tooth damage. Enamel is located on the outermost surface of teeth and has the strongest mechanical strength in the human body. It is a highly mineralized tissue composed of hydroxyapatite (HAP). Therefore, enamel provides sufficient hardness to teeth and provides basic functions such as chewing. However, since enamel is the outermost surface of the tooth, caries also occurs first in the enamel layer. In humans, ename...

Claims

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Application Information

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IPC IPC(8): A61K6/033C01B25/32A61K6/838
CPCA61K6/838C01B25/32
Inventor 刘昭明邵长鹆唐睿康
Owner ZHEJIANG UNIV
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