Purification method of crude moxidectin product

A moxidectin and purification method technology, which is applied in the field of antibiotic extraction, can solve the problems of ineffective removal of moxidectin impurities and low effective content of finished products, so as to improve international market competitiveness, low production cost, and high production efficiency. short cycle effect

Active Publication Date: 2017-11-24
宁夏泰瑞制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with this method is that the method of recrystallization cannot effectively remove the impu

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] To 10kg of crude moxidectin, add 110L of purified water, 0.3kg of polyaluminum chloride H8150 and 0.04kg of adsorbent NSUL-20.04kg, adjust the pH to 7.5 with lye, and stir for 20min.

[0028] Add 70L of butyl acetate, stir for 40min, and filter.

[0029] The mixed solution was allowed to stand for 60 min, and then layered and filtered to obtain 64.4 L of moxidectin butyl acetate solution.

[0030] During the adsorption process, the ultra-high cross-linked adsorption resin used was Ambeilite XAD-6, the dosage was 30kg, and the adsorption flow rate was controlled at 3L / min.

[0031] During the analysis process, the analysis liquid is acetone, and its dosage is 60.7L, and the analysis flow rate is controlled at 5L / min.

[0032] Add 183L of purified water to the moxidectin organic solution, and raise the temperature to 48°C, continue to add purified water, the flow rate of purified water is controlled at 6L / min, stop adding purified water after crystallization occurs, cont...

Embodiment 2

[0036] To 10kg of crude moxidectin, add 120L of purified water, 0.35kg of polyaluminum chloride H8150 and 0.05kg of adsorbent NSUL-20.05kg, adjust the pH to 7.6 with lye, and stir for 23min.

[0037] Add 75L of butyl acetate, stir for 45min, and filter.

[0038] The mixed solution was allowed to stand for 65 minutes, and then layered and filtered to obtain 69 L of moxidectin butyl acetate solution.

[0039] During the adsorption process, the ultra-high cross-linked adsorption resin used was Ambeilite XAD-6, the dosage was 35kg, and the adsorption flow rate was controlled at 3.2L / min.

[0040] During the analysis process, the analysis liquid is acetone, and its consumption is 65.4L, and the analysis flow rate is controlled at 5.2L / min.

[0041] Add 229L of purified water to the moxidectin organic solution, and raise the temperature to 48.5°C, continue to add purified water, the flow rate of purified water is controlled at 6.5L / min, stop adding purified water after crystallizat...

Embodiment 3

[0045] To 10kg of crude moxidectin, add 130L of purified water, 0.4kg of polyaluminum chloride H8150 and 0.06kg of adsorbent NSUL-20.06kg, adjust the pH to 7.7 with lye, and stir for 25min.

[0046] Add 80L of butyl acetate, stir for 50min, and filter.

[0047] The mixed solution was allowed to stand for 70 min, and then layered and filtered to obtain 74 L of moxidectin butyl acetate solution.

[0048] During the adsorption process, the ultra-high cross-linked adsorption resin used was Ambeilite XAD-6, the dosage was 40kg, and the adsorption flow rate was controlled at 3.5L / min.

[0049] During the analysis process, the analysis liquid is acetone, and its dosage is 70L, and the analysis flow rate is controlled at 5.5L / min.

[0050] Add 280L of purified water to the moxidectin organic solution, and raise the temperature to 49°C, continue to add purified water, the flow rate of purified water is controlled at 7L / min, stop adding purified water after crystallization occurs, cont...

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Abstract

The invention relates to a purification method of a crude moxidectin product. The purification method comprises the following process steps: dissolving the crude moxidectin product, performing resin adsorption, crystallizing and drying to obtain a pure moxidectin product. By the purification method, moxidectin is extracted and purified through the resin adsorption, impurities in the moxidectin are removed to the maximum extent, the finished product content of the moxifloxacin is effectively increased, the finished product content thereof reaches 97% or above, and the product quality accords with the quality standard specified in European Pharmacopoeia; meanwhile, by the purification method, the process is simple, the production cycle is short, the production cost is low, and improvement on the competitiveness of the mothocetin in the international market is facilitated.

Description

technical field [0001] The invention belongs to the technical field of antibiotic extraction, in particular to a method for purifying crude moxidectin. Background technique [0002] Moxidectin (MXD) is a broad-spectrum, high-efficiency, new macrolide anthelmintic antibiotic widely used in veterinary clinics, and is a member of the mebemycin family. MXD is a semi-synthetic single-component macrolide antibiotic produced by the fermentation of Streptomyces, which is a derivative of neimamicin. The difference between MXD and other macrolide antiparasitic drugs and abamectin is that it is a single component, has higher anthelmintic activity, long-acting, safety and other characteristics, and has a very low dose It has strong anti-parasite activity such as nematodes and arthropods, and has been used as an anthelmintic for animals since the mid-1980s. [0003] At present, the domestic public literature briefly describes the use of ethanol to extract neimamectin, obtain the crude ...

Claims

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Application Information

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IPC IPC(8): C07D493/22
CPCC07D493/22
Inventor 王大卫赵海兵
Owner 宁夏泰瑞制药股份有限公司
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