Veterinary-use radix daphniphylli calycini and red-knees herb granule and application thereof to chicken necrotic enteritis

A granule, the technology of Fengyao, which is applied in the field of veterinary Fengyao granule and its application in chicken necrotic enteritis, can solve the problems of harming the human body, water and soil pollution, and potential safety hazards, and achieve the reduction of exudation, The effect of preventing chicken diarrhea

Active Publication Date: 2017-12-01
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Some people in the industry said that human medicine has not been tested on animals, including dosage and safety tests. If human medicine is used for veterinary use, the dose is not accurate, and there is a great potential safety hazard
In addition, human

Method used

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  • Veterinary-use radix daphniphylli calycini and red-knees herb granule and application thereof to chicken necrotic enteritis
  • Veterinary-use radix daphniphylli calycini and red-knees herb granule and application thereof to chicken necrotic enteritis
  • Veterinary-use radix daphniphylli calycini and red-knees herb granule and application thereof to chicken necrotic enteritis

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0065] Example 1 An extraction process of Polygonum vulgare

[0066] Weigh 20g of Polygonum vulgare powder (Niu'erfeng: Polygonum vulgare = 2:1) and place it in a 500ml round-bottom flask. Use ethanol with a concentration of 55%-75% by volume as the extraction solvent. The amount of ethanol solution added is Niu'erfeng It is 8-12 times of the mixture with Polygonum vulgare, soaked for 1 hour, and then subjected to reflux extraction. The extraction time is 60-120min, and the extraction times are 1-3 times. According to different ethanol concentration, ethanol solution addition amount, extraction times, and reflux time, 7 treatment groups were set up. See Table 1 for details. The extracts were filtered and combined to obtain the alcohol extract of Fengfeng.

[0067] Table 1 Ethanol extraction process of Feng Liao

[0068]

[0069] Control water as the extraction solvent. Weigh 20g of Polygonum vulgare powder (Niu'erfeng: Polygonum sylvestris = 2:1) and place it in a 500ml round-botto...

Example Embodiment

[0138] Example 2 A preparation process of Fengliao granules

[0139] Mix 1160g Niu'erfeng and 580g Polygonum serrata, add 10 times the weight of 65% ethanol to reflux extraction twice, 60min each time, combine the extracts; centrifuge the combined extracts at 6000r / min for 10min; take the supernatant Concentrate under reduced pressure at 0.08mpa at 60℃ to a relative density of 1.15~1.25 to obtain Polygonum vulgare extract. The extraction rate is 23%. The average content of total flavonoids in the extract is 30.28±0.45mg / g; vacuum dried at 80℃ to powder , Get 400g of the extract of Polygonum fortunei, and the content of total flavonoids in the extract of Polygonum fortunei is 18.67±0.58mg / g.

[0140] Dextrin and sucrose were mixed according to the weight ratio of 3:2 to obtain the auxiliary materials. The extract of Fengliao extract and the auxiliary materials were mixed according to the weight ratio of 1:1.5, and 85% ethanol was used as a wetting agent for wet granulation, passed t...

Example Embodiment

[0145] Example 3 A preparation process of Fengliao granules

[0146] Mix 1160g Niu'erfeng and 580g Polygonum serrata, add 10 times of 65% ethanol and reflux for 2 times, 60min each time, combine the extracts; centrifuge the combined extracts at 6000r / min for 10min; take the supernatant at 0.08 It was concentrated under reduced pressure at 50°C-70°C under mpa to a relative density of 1.15~1.25 to obtain Polygonum vulgare extract. The average content of total flavonoids in the extract was determined. The experimental results are shown in Table 12. The extract was vacuum dried at 80°C into a powder to obtain the Feng Liao extract.

[0147] Table 12 Table of results of concentration test (n=3)

[0148]

[0149] It can be seen from Table 12 that the total flavonoid content is the highest at 60°C, and the lowest at 70°C. There is little difference between 50°C and 60°C, while the difference between 70°C and 60°C is relatively large. The higher the temperature, the concentration time The ...

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Abstract

The invention discloses a veterinary-use radix daphniphylli calycini and red-knees herb granule and application thereof to chicken necrotic enteritis. The radix daphniphylli calycini and red-knees herb granule is prepared from radix daphniphylli calycini, red-knees herb and auxiliary materials, wherein the active ingredients of the radix daphniphylli calycinum and the red-knees herb in the radix daphniphylli calycini and red-knees herb granule are radix daphniphylli calycini and red-knees herb extracts obtained through performing reduced pressure concentration and vacuum drying on the radix daphniphylli calycini and red-knees herb alcohol extraction liquid; the auxiliary materials are a mixture of dextrin and saccharose. The alcohol extraction process of the radix daphniphylli calycini and red-knees herb is optimized; under the optimum process conditions, 33.01+/-0.30mg/g of general flavone, 271.31+/-0.37 mug/g of quercetin and 23.16+/-0.47 percent of extraction rate can be realized. Through the study, the analgesic effect of the radix daphniphylli calycini and red-knees herb granule on the nervus centralis is a little weaker than the analgesic effect on peripheral nerves; the effusion of early-stage inflammatory tissue fluid can be effectively reduced; the dose-effect relationship is shown, i.e., the inhibition rate is higher when the dose is greater; when the granule is combined with antibiotics, the chicken necrotic enteritis can be effectively prevented and treated.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a veterinary Fengyao granule and its application in chicken necrotic enteritis. Background technique [0002] Acute and chronic gastroenteritis is a common and frequently-occurring disease. Clinically, abdominal discomfort, abdominal pain, nausea and vomiting, abdominal distension and diarrhea, belching and pantothenic acid, and loss of appetite are the main clinical manifestations. The cause of the disease is often overeating and unclean diet Due to history. It has been found in clinical medicine that the Fengyao preparation composed of Niuerfeng and Cape Polygonum has the functions of regulating qi, invigorating the stomach, dehumidification and stagnation, and is used for acute gastroenteritis and abdominal distension caused by unhealthy middle movement, stagnation of qi and dampness. , abdominal pain and diarrhea and other dyspepsia, clinically achieved good re...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K45/06A61K9/16A61P1/12A61P29/00A61P31/04A61K31/43
CPCA61K9/1652A61K31/43A61K36/185A61K36/704A61K45/06A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 彭新宇蒋琪高彪袁明贵尹烨华徐志宏
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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