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Compound peanut red-skin blood supplementing oral liquid and quality detection method thereof

A technology of oral liquid and red coat, which is applied in the field of compound Hongyi Buxue oral liquid and its quality inspection, can solve the problems of loss of active ingredients of polysaccharides, poor stability performance, increased cost of raw materials, etc., achieve simple and feasible preparation method, and improve dissolution rate , to avoid the effect of enzyme treatment

Active Publication Date: 2017-12-01
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant's previous patented technologies 2008101590994 and 2015101684898 both involved the improvement of Compound Hongyi Oral Liquid. Among them, the patented technology 2008101590994 involved the improvement of the extraction process. Through the improvement of the extraction process of different raw materials, the efficacy of the drug was improved, but among them, peanut red Clothes can obtain higher amounts of proanthocyanidins, resveratrol, etc. through the above process, but it is not easy to use the above process for medlar and jujube, which will cause the loss of active ingredients of polysaccharides; patented technology 2015101684898 is based on the existing formula, adding The cost of a variety of Chinese herbal medicines has been reduced, but this method has greatly increased the cost of raw materials, and the stability is relatively poor

Method used

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  • Compound peanut red-skin blood supplementing oral liquid and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound red coat blood-tonifying oral liquid, which comprises the following raw materials:

[0028] Fungus, wolfberry, jujube, peanut red coat, honey, sucrose, citric acid and stabilizer.

[0029] Specifically, the compound Hongyi Buxue Oral Liquid is prepared according to the following process:

[0030] 1) Take 20g of fungus, add 16 times the weight of water, soak for 30 minutes, heat to a slight boil for 2 hours, filter, add 10 times the weight of water to the dregs, heat and boil for 1 hour, filter, combine the filtrates, and concentrate to The density is 1.02g / ml, and the fungus extract is obtained;

[0031] 2) Take 100g of Lycium barbarum, crush it, add 5 times the weight of water, and cut it with a high-speed shearer for 60 minutes to obtain the soaking liquid. % ethanol, and the control pressure is 0.8Mpa, the temperature is 60°C, 300rpm is stirred and extracted for 120min, the filtrate is collected by filtration, then the filtrate is evaporated under reduce...

Embodiment 2

[0038] The quality detection method and the detection standard of the compound red coat blood-reinforcing oral liquid of the present invention:

[0039] The testing standard is shown in Table 1

[0040] Table 1

[0041]

[0042] Conclusion: The product prepared in Example 1 of the present invention fully complies with statutory standards and internal control standards.

[0043] The detection method is: take 10ml of this product, add hydrochloric acid to adjust the pH value to 2-3, extract 3 times with water-saturated ether, 10ml each time, combine the ether solution, evaporate the ether, add 1ml of methanol to the residue to dissolve, and use it as the test sample solution. Take another 2 g of peanut red-coated reference medicinal material, add 50 ml of water, boil for 15 minutes, filter, add hydrochloric acid to the filtrate to adjust the pH value to 2-3, and prepare a peanut red-coated reference medicinal material solution in the same way. Then take Fructus Lycium barb...

Embodiment 3

[0048] Study on the Stability of Oral Liquid

[0049] Light irradiation effect test:

[0050] Group 1: xanthan gum; group 2: chitosan; group 3 (Example 1): xanthan gum: chitosan = 2:1; the addition amount is exactly the same, which has comparative significance.

[0051] Divide the oral liquid into 3 groups, 20 in each group, and place the oral liquid in the three groups under the condition of 200w light for 20 days at the same time, randomly take 2 oral liquids from each group for testing at the same time; see Table 2 for details

[0052] check indicators

Before light treatment

group 1

group 2

group 3

Exterior

orange yellow

orange yellow

orange yellow

orange yellow

Clarity

clarification

Slightly flocculent or fluffy

Slightly flocculent or fluffy

clarification

pH

4.0

3.9

3.8

4.0

[0053] Temperature influence test:

[0054] Group 1: xanthan gum; group 2: chitosan; group 3 (Example 1...

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Abstract

The invention belongs to the technical field of drug extraction, and discloses compound peanut red-skin blood supplementing oral liquid. The compound peanut red-skin blood supplementing oral liquid is prepared from the following raw materials: Exidia auricula Judaefungus, fructus lycii, fructus jujubae, peanut red skin, honey, cane sugar, citric acid and a stabilizer. The oral liquid is has the advantages of unique in extraction process, good in drug effect, good in clarity, free fromno turbidity and precipitation and good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a compound Hongyi Buxue oral liquid and a quality detection method thereof. Background technique [0002] Anemia refers to a common clinical symptom in which the volume of red blood cells in the peripheral blood of the human body is low, which is lower than the lower limit of the normal range. Because the determination of red blood cell volume is complicated, it is often replaced by hemoglobin (Hb) concentration in clinical practice. The main causes of anemia are: (1) iron deficiency; (2) decreased EPO production; (3) metabolic poisons inhibit the proliferation of red blood cells; (4) inflammatory factors accelerate the removal of antibodies or immune complexes in the circulation (5) The increased generation of reactive oxygen species in CKD patients makes red blood cells prone to hemolysis. Clinical manifestations: (1) Nervous system: dizziness, tinnitu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/08A61P7/06G01N21/29G01N21/80G01N30/90A61K35/644
CPCA61K9/0095A61K35/644A61K36/07A61K36/48A61K36/725A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2236/51G01N21/29G01N21/80G01N30/90A61K2300/00
Inventor 林凡儒林祥宇王世礼罗晓倩王维才
Owner XIANGYU PHARMA
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