Artificial biological cardiac and vascular valve on basement membrane component surface layer and preparation method thereof

A biological valve, basement membrane technology, applied in tissue regeneration, drug delivery, pharmaceutical formulations, etc., can solve the problem of biocompatibility cytotoxicity is not significantly better, lack of in vivo data and long-term implantation results report, rapid degradation, degradation Uncontrollable time and other problems, to achieve the effect of good blood compatibility, prolong the use period and reduce immunogenicity

Pending Publication Date: 2017-12-01
EXCELLENCE MEDICAL TECH SUZHOU CO LTD +1
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Problems solved by technology

CN101690829A uses nordihydroguaiaretic acid to cross-link the porcine aortic valve, and CN10135870A uses epichlorohydrin to cross-link the decellularized valve. At present, the biocompatibility, immunogenicity in animal experiments, and cytotoxicity are not significantly better than pentadiene Aldehydes, and lack of in vivo...

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  • Artificial biological cardiac and vascular valve on basement membrane component surface layer and preparation method thereof

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Embodiment 1

[0029] Fresh porcine aortic valves were taken, cleaned and treated with Triton X-100 solution for 2 hours, rinsed, and cross-linked with glutaraldehyde to obtain biological valve materials; the basement membrane layer derived from porcine skin was separated, washed, degreased, thoroughly decellularized, After washing, the surface layer of the basement membrane component is prepared; the surface layer of the basement membrane component is tightly wrapped around the outer surface of the biological valve material, bonded with a medical chitosan adhesive, and pressed together under -200mmHg. Tissue section, HE staining can observe the complete basement membrane components on the surface of the material. The following experiments all take the biological valve material wrapped with the basement membrane component prepared in this example as the experimental group. The control group was prepared from fresh aortic valves cross-linked with glutaraldehyde. Embedded section, HE staining...

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Abstract

The invention relates to an artificial biological cardiac and vascular valve on a basement membrane component surface layer and a preparation method thereof. The artificial biological cardiac and vascular valve comprises a biovalve material and the basement membrane component surface layer tightly covering the biovalve material. On the basis that the good strength and toughness of a crosslinking biovalve are reserved, rapid endothelialization of the smooth and dense basement membrane component surface layer can be achieved, and calcium salt deposition can be obstructed, so that cytotoxicity and immunogenicity reducing which are caused by calcification and isolation crosslinking of the biovalve are prevented, and the service life of the artificial biological cardiac and vascular valve is prolonged.

Description

technical field [0001] The invention belongs to the field of artificial biological heart / vascular valve and its preparation, in particular to an artificial biological heart / vascular valve with basement membrane component surface layer and its preparation method. Background technique [0002] Artificial heart valve replacement is the main treatment for valve disease. Mechanical valves are durable, but anticoagulant drugs need to be taken for life, the incidence of thromboembolism is high, and bleeding complications may occur. Biological valves have similar hydrodynamic properties to human heart valves and are more biocompatible than mechanical valves, and patients only need short-term or no anticoagulant drugs. However, easy calcification, poor durability, and certain immunogenicity are the main factors limiting the application of biological valves. Phosphate groups contained in cell debris or cell membranes, and the exposure of carboxyl groups, aldehyde groups, amino group...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/36
CPCA61L27/3604A61L27/3616A61L27/362A61L27/3629A61L27/3641A61L2400/02A61L2430/20
Inventor 张剑
Owner EXCELLENCE MEDICAL TECH SUZHOU CO LTD
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