Sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles and preparation method thereof

Abstract

The invention provides a sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles, which is prepared from the following raw materials in the weight ratio: 1-100 parts of tetrahydrocurcumin, polyethylene glycol ‑Polylactic acid block copolymer (MPEG‑PLA) 20-2000 parts, chitosan 2000 parts, sodium alginate 2000 parts. The invention also provides the preparation method and application of the dressing. The present invention adds the healing-promoting tetrahydrocurcumin nanoparticles into the sodium alginate-chitosan foam dressing, so that it has the healing-promoting effect of tetrahydrocurcumin and the high hygroscopicity and nontoxicity of sodium alginate. , low immunogenicity, and good healing promotion, hemostasis, non-toxic, biodegradable compatibility of chitosan, which is beneficial to the growth and regeneration of wound tissue, antibacterial, anti-inflammatory, accelerates wound healing, and is convenient for storage and use. An excellent medical dressing.

Description

technical field

[0001] The invention relates to a method for preparing a sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles. Background technique

[0002] In clinical treatment of patient wounds, it is generally necessary to cover the wound with a dressing to prevent bacterial invasion and maintain a moist environment on the wound. Although traditional dressings such as gauze and cotton pads can protect the wound surface, they do not have the performance of treating and repairing the wound; traditional auxiliary materials cannot keep the wound moist and delay wound healing; It is easy to cause secondary damage to the wound; traditional dressings have poor biodegradability and are difficult to remove from the wound. Therefore, using biomaterials to prepare dressings, or adding other excipients with excellent healing properties, such as antibiotics and nano-gold, to dressings has reached a broad consensus in clinical application and scientific rese...

Examples

Embodiment 1

[0041] Embodiment 1 The preparation method of the sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles of the present invention

[0042] Weigh 1 gram of sodium alginate and dissolve it in 50 milliliters of deionized water to obtain a sodium alginate hydrogel solution; weigh 1 gram of chitosan and dissolve it in 50 milliliters of deionized water to obtain a chitosan hydrogel solution. According to the ratio of 1:20, weigh 0.5 mg of tetrahydrocurcumin and 10 mg of carrier material MPEG-PLA, dissolve them in 2 ml of dichloromethane solvent, and remove the dichloromethane by rotary evaporation on a rotary evaporator at 60°C Finally, 5 mL of deionized water was added and shaken slightly, so that the material and drug self-assembled to form drug-loaded nanoparticles were completely dissolved in water to obtain a tetrahydrocurcumin nanoparticle solution. The tetrahydrocurcumin nanoparticle solution is slowly added dropwise into the sodium alginate hydrogel s...

Embodiment 2

[0044] Embodiment 2 The preparation method of the sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles of the present invention

[0045] Weigh 1 gram of sodium alginate and dissolve it in 50 milliliters of deionized water to obtain a sodium alginate hydrogel solution; weigh 1 gram of chitosan and dissolve it in 50 milliliters of deionized water to obtain a chitosan hydrogel solution. According to the ratio of 1:20, weigh 5 mg of tetrahydrocurcumin and 100 mg of carrier material MPEG-PLA, dissolve them in 2 ml of dichloromethane solvent, and remove the dichloromethane by rotary evaporation on a rotary evaporator at 60°C Finally, 5 mL of deionized water was added and shaken slightly, so that the material and drug self-assembled to form drug-loaded nanoparticles were completely dissolved in water to obtain a tetrahydrocurcumin nanoparticle solution. The tetrahydrocurcumin nanoparticle solution is slowly added dropwise into the sodium alginate hydrogel so...

Embodiment 3

[0046] Embodiment 3 The preparation method of the sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles of the present invention

[0047] Weigh 1 gram of sodium alginate and dissolve it in 50 milliliters of deionized water to obtain a sodium alginate hydrogel solution; weigh 1 gram of chitosan and dissolve it in 50 milliliters of deionized water to obtain a chitosan hydrogel solution. According to the ratio of 1:20, weigh 20 mg of tetrahydrocurcumin and 400 mg of carrier material MPEG-PLA, dissolve them in 2 ml of dichloromethane solvent, and remove the dichloromethane by rotary evaporation on a rotary evaporator at 60°C Finally, 5 mL of deionized water was added and shaken slightly, so that the material and drug self-assembled to form drug-loaded nanoparticles were completely dissolved in water to obtain a tetrahydrocurcumin nanoparticle solution. The tetrahydrocurcumin nanoparticle solution is slowly added dropwise into the sodium alginate hydrogel s...

technical field

[0001] The invention relates to a method for preparing a sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles. Background technique

[0002] In clinical treatment of patient wounds, it is generally necessary to cover the wound with a dressing to prevent bacterial invasion and maintain a moist environment on the wound. Although traditional dressings such as gauze and cotton pads can protect the wound surface, they do not have the performance of treating and repairing the wound; traditional auxiliary materials cannot keep the wound moist and delay wound healing; It is easy to cause secondary damage to the wound; traditional dressings have poor biodegradability and are difficult to remove from the wound. Therefore, using biomaterials to prepare dressings, or adding other excipients with excellent healing properties, such as antibiotics and nano-gold, to dressings has reached a broad consensus in clinical application and scientific rese...

Examples

Embodiment 1

[0041] Embodiment 1 The preparation method of the sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles of the present invention

[0042] Weigh 1 gram of sodium alginate and dissolve it in 50 milliliters of deionized water to obtain a sodium alginate hydrogel solution; weigh 1 gram of chitosan and dissolve it in 50 milliliters of deionized water to obtain a chitosan hydrogel solution. According to the ratio of 1:20, weigh 0.5 mg of tetrahydrocurcumin and 10 mg of carrier material MPEG-PLA, dissolve them in 2 ml of dichloromethane solvent, and remove the dichloromethane by rotary evaporation on a rotary evaporator at 60°C Finally, 5 mL of deionized water was added and shaken slightly, so that the material and drug self-assembled to form drug-loaded nanoparticles were completely dissolved in water to obtain a tetrahydrocurcumin nanoparticle solution. The tetrahydrocurcumin nanoparticle solution is slowly added dropwise into the sodium alginate hydrogel s...

Embodiment 2

[0044] Embodiment 2 The preparation method of the sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles of the present invention

[0045] Weigh 1 gram of sodium alginate and dissolve it in 50 milliliters of deionized water to obtain a sodium alginate hydrogel solution; weigh 1 gram of chitosan and dissolve it in 50 milliliters of deionized water to obtain a chitosan hydrogel solution. According to the ratio of 1:20, weigh 5 mg of tetrahydrocurcumin and 100 mg of carrier material MPEG-PLA, dissolve them in 2 ml of dichloromethane solvent, and remove the dichloromethane by rotary evaporation on a rotary evaporator at 60°C Finally, 5 mL of deionized water was added and shaken slightly, so that the material and drug self-assembled to form drug-loaded nanoparticles were completely dissolved in water to obtain a tetrahydrocurcumin nanoparticle solution. The tetrahydrocurcumin nanoparticle solution is slowly added dropwise into the sodium alginate hydrogel so...

Embodiment 3

[0046] Embodiment 3 The preparation method of the sodium alginate-chitosan dressing loaded with tetrahydrocurcumin nanoparticles of the present invention

[0047] Weigh 1 gram of sodium alginate and dissolve it in 50 milliliters of deionized water to obtain a sodium alginate hydrogel solution; weigh 1 gram of chitosan and dissolve it in 50 milliliters of deionized water to obtain a chitosan hydrogel solution. According to the ratio of 1:20, weigh 20 mg of tetrahydrocurcumin and 400 mg of carrier material MPEG-PLA, dissolve them in 2 ml of dichloromethane solvent, and remove the dichloromethane by rotary evaporation on a rotary evaporator at 60°C Finally, 5 mL of deionized water was added and shaken slightly, so that the material and drug self-assembled to form drug-loaded nanoparticles were completely dissolved in water to obtain a tetrahydrocurcumin nanoparticle solution. The tetrahydrocurcumin nanoparticle solution is slowly added dropwise into the sodium alginate hydrogel s...

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