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Uses of myocarditis protein marker

A technology of myocarditis and protein, applied in the direction of biomaterial analysis, measuring device, material analysis by electromagnetic means, etc.

Inactive Publication Date: 2017-12-05
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current diagnostic methods mainly rely on the patient's history of infection, electrocardiogram and cardiac imaging findings, but due to the complexity of its clinical manifestations, the correct diagnosis of myocarditis is a great challenge

Method used

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  • Uses of myocarditis protein marker
  • Uses of myocarditis protein marker
  • Uses of myocarditis protein marker

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Embodiment Construction

[0029] The present invention will be further illustrated by the following non-limiting examples. Those skilled in the art know that many modifications can be made to the present invention without departing from the spirit of the present invention, and such modifications also fall within the scope of the present invention.

[0030] The following experimental methods are conventional methods unless otherwise specified, and the experimental materials used can be easily obtained from commercial companies unless otherwise specified.

[0031] Materials and reagents

[0032] 1) Apparatus: Rat metabolic cage: purchased from Beijing Jiayuan Xingye Technology Co., Ltd. TripleTOF 5600 mass spectrometer: purchased from ABI company; Waters UPLC high performance liquid chromatograph: purchased from Waters company; MillliQ RG ultrapure water system: purchased from Millipore company; C18 reverse phase analytical column (RP column, 0.1×150mm, 3μm, ): purchased from MichromBioresources.

[0033] 2) Ma...

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Abstract

The present invention relates to the use of protein markers of myocarditis, in particular to the use of binding moieties that selectively bind to one or more proteins in the preparation of reagents for diagnosing human myocarditis diseases, wherein the one or more proteins The human protein corresponding to the differential protein obtained from the autoimmune myocarditis rat model and the normal rat mass spectrometry analysis. Specifically, the present invention relates to the use of potential markers of human myocarditis urinary protein obtained by using a rat model and mass spectrometry analysis.

Description

Technical field [0001] The present invention relates to the use of protein markers for myocarditis. Specifically, the present invention relates to the use of protein markers related to the diagnosis of human myocarditis obtained by using an autoimmune myocarditis rat model and mass spectrometry analysis. Background technique [0002] The significance of urinary proteomics in the study of kidney disease: [0003] Unlike blood, which has the ability to maintain homeostasis, urine is more prone to changes. These changes reflect changes in bodily functions, that is, urine is an important source of biomarkers, see Youhe G. Can urine be the goldmine for biomarker discovery ? .Sci China Life Sci 2013; 43.. [0004] Urine can often show the function of the urinary system to a certain extent, and it is convenient and simple to use urine changes to diagnose kidney disease. Changes in urinary system function are not easy to detect. The current diagnosis methods mainly rely on biopsy, which ...

Claims

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Application Information

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IPC IPC(8): G01N27/62
CPCG01N33/6848G01N2800/32G01N2800/52
Inventor 高友鹤赵敏迪李逊斗
Owner BEIJING NORMAL UNIVERSITY
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