A screening method for chemical risk substances of quinolone antibiotics in toiletries

A technology for quinolones and toiletries, which is applied in the screening field of chemical risk substances of quinolone antibiotics, can solve the problems of lagging supervision of chemical risk substances, insufficient prevention ability, unreported detection methods, etc., and achieve sustainable and healthy development , promote healthy and standardized development, and standardize the effects of market economic rules and business order

Active Publication Date: 2020-05-22
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. The supervision of chemical risk substances in toiletries is relatively lagging behind, and the prevention ability is insufficient
However, there is no report on the detection method of toilet products using high-resolution mass spectrometry.

Method used

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  • A screening method for chemical risk substances of quinolone antibiotics in toiletries
  • A screening method for chemical risk substances of quinolone antibiotics in toiletries
  • A screening method for chemical risk substances of quinolone antibiotics in toiletries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for detecting chemical risk substances of quinolone antibiotics in toiletries, comprising the steps of:

[0051] After the pretreatment steps of extraction, centrifugation, purification, filtration and other pretreatment steps, the sample solution obtained by ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection; ultra-high pressure liquid chromatography-quadrupole In rod-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection, the chromatographic separation conditions are as follows:

[0052] Column: Waters ACQUITY UPLC BEH C 18 , 100mm×2.1mm i.d., 1.7μm, column temperature: 35℃; flow rate: 0.3mL min -1 ;Injection volume: 5μL, see Table 1 for mobile phase and gradient elution program:

[0053] Table 1 Chromatographic mobile phase and gradient elution program

[0054]

[0055] In the ultra-high pressure liquid chromatography-quadrupole-electr...

Embodiment 2

[0063] 1. Instruments and reagents

[0064] Dionex UltiMate 3000 fast high-performance liquid chromatography system (Thermo Fisher, USA); QExactive Focus quadrupole-electrostatic field orbitrap high-resolution mass spectrometer (Thermo Fisher, USA); Milli-Q ultrapure water instrument (Millipore, USA); Vortex-Genie 2 vortex oscillator (Scientific Industries, USA).

[0065] Methanol, acetonitrile (chromatographically pure, American Thermo Fisher Company); ammonium hydroxide, formic acid (chromatographically pure, American DimaTechnology Company); laboratory water is deionized water. Carbon eighteen, N-propyl ethylenediamine and graphitized carbon black (Germany Macherey-Nagel company); Multi-wall carbon nanotubes (Germany Miltenyi Biotec GmbH company); Anhydrous magnesium sulfate, sodium chloride (Guangzhou Xilong Chemical Industry limited liability company); 0.22 μm microporous membrane (Pall Corporation, USA).

[0066] Prepare 500-1000μg mL respectively -1 The standard stoc...

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Abstract

The invention discloses a screening method for chemical risky substances of quinolone antibiotics in wash supplies. The method comprises the following steps: (1) establishing a precise quality database and a mass spectrum library of to-be-tested compounds; (2) pre-treatment and detection of an actual sample: performing pre-treatment steps of extraction, centrifugalization, purification, filtration and the like on a sample of the wash supplies, and performing ultrahigh pressure liquid chromatogram-quadrupole rod-electrostatic field orbitrap high resolution mass spectrum analysis and detection; and (3) comparing and analyzing the test result obtained in the step (2) with the precise quality database and the mass spectrum library established in the step (1) to screen the chemical risky substances of quinolone antibiotics in wash supplies. The screening method for chemical risky substances of quinolone antibiotics in wash supplies disclosed by the invention is high in accuracy, high in specificity and high in sensitivity, and is suitable for daily detection and quality control of the wash supplies.

Description

technical field [0001] The present invention relates to a method for screening chemical substances, in particular to a method for screening chemical risk substances of quinolone antibiotics in toiletries based on ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry screening method. Background technique [0002] 1. Chemical risk substances in toiletries have potential harmful effects on consumers' personal health. [0003] From the very beginning of its birth, toiletries have provided protection for people's pursuit of a clean, healthy and fashionable life. With the continuous development and progress of society, people's pursuit of a clean, healthy and fashionable lifestyle has also been continuously upgraded, thus driving the development of toiletries. The industry has stepped into the fast lane of development and upgrading. At present, there are a wide variety of products in the cleaning and care products ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/027
Inventor 马强孟宪双白桦郭项雨胡明珠吕悦广闫萌萌陈萌
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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