Streptovaricin derivative and preparation method and application thereof

A technology for streptothricin and derivatives, which is applied in the field of novel streptomycin derivatives and their preparation, can solve problems such as unclear steps, and achieve the effects of rich diversity and good antibacterial effect
CN107540682AActive Publication Date: 2018-01-05WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV
Publication Date
2018-01-05

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Abstract

The invention discloses a streptozotocin derivative and a preparation method and application thereof, and belongs to the field of biomedicine. According to the invention, a streptozotocin spectabilisXW-1 (preservation number is CCTCC NO: M2017417) is used as an original strain, and P450 genes (stvP4 and stvP5) in the post-modification system of streptozotocin biosynthetic gene cluster are respectively singly inactivated or deleted. Through separation and purification of a crude extract of a fermentation product of the two mutant strains, a novel streptozotocin derivative 1-4 is obtained. Thenovel streptozotocin derivative has good antibacterial effect, provides a new solution for the problem of antibiotic resistance, and provides a basis for structural modification of streptozotocin antibiotic.
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Description

technical field

[0001] The invention relates to the field of streptothricin preparation, in particular to novel streptothricin derivatives and their preparation methods and applications. Background technique

[0002] Since the 1960s, antibiotic resistance has gradually become a serious threat to public health, causing many difficult-to-treat human infections and even death. In particular, Methicillin-resistant Staphylococcus aureus (MRSA) is now considered a "superbug" that causes major human illness and death, due to its high virulence and wide distribution (such as community and hospital environments ), which can cause huge economic losses. Therefore, there is an urgent need to develop new drugs against these pathogens. Natural products have been proven to be important resources for the discovery of anti-MRSA antibiotics such as vancomycin and daptomycin; on the other hand, engineered biosynthesis can complement this traditional time-consuming and labor-intensive drug di...

Claims

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