A kind of nitroimidazole drug and its preparation method and application

Abstract

The present invention relates to a novel nitroimidazole compound and its preparation method and application in medicine. Specifically, the present invention relates to a nitroimidazole compound represented by general formula (I), its preparation method and the Pharmaceutical compositions of compounds. The object of the present invention is to synthesize a series of new compounds of nitroimidazole derivatives by modifying the structure of nitroimidazole compounds. These compounds can obviously reduce the adverse reactions in clinical practice. It has an ideal protective effect, and its clinical application is obvious.

Description

A kind of nitroimidazole medicine and its preparation method and use technical field The invention belongs to technical field of medicinal chemistry, be specifically related to nitroimidazole medicine and preparation method and purposes thereof. Background technique At present in infectious diseases, the most common type is bacterial infection, if lack of timely and effective treatment, serious can lead to high mortality. such as Campylobacter, Salmonella, E. coli O157 and Listeria monocytogenes annually Foodborne diseases caused by bacteria bring huge economic losses and threats to human life. Antibiotics are considered to be the most beneficial weapons for the treatment of bacterial infectious diseases, however, with the abuse of antibiotics The problem of bacterial resistance is getting worse and worse, and the rate of research and development of new antibiotics is far slower than the rate of drug-resistant bacteria. Research shows that 25% of Streptococcus pne...

AI Technical Summary

Problems solved by technology

However, nitroimidazole can cause genital erosion, flake hemorrhage, skin allergies, oral ulcers, nausea, stomach discomfort and other adverse reactions after oral administration, which can easily cause rejection in patients and is not conducive to medication.

Images