Magnolia bark exhaust medicament, taste-masking method for magnolia bark exhaust medicament and preparation method thereof

Abstract

The invention belongs to the technical field of pharmaceutic preparations and specifically relates to a magnolia bark exhaust medicament, a taste-masking method for the magnolia bark exhaust medicament and a preparation method thereof. The taste-masking method for the magnolia bark exhaust medicament comprises the step of adding a clathration agent, a taste inhibitor, a correcting agent, a sweetener, an aromatic agent and a preservative for masking taste. According to the taste-masking method provided by the invention, the spicy taste of the preparation and the stimulation to throat are effectively reduced and the compliance of the patient is promoted; the magnolia bark exhaust medicament according to the taste-masking method is free from spicy taste and has slight stimulation to throat; the preparation method is simple in process and is easy for implementation.

Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a taste-masking method of a magnolia bark exhaust mixture, a magnolia bark exhaust mixture and a preparation method thereof. Background technique

[0002] Decreased gastrointestinal motility after pelvic and abdominal surgery is a common complication after gynecological surgery, manifested as abdominal distension, anorexia, defecation without exhaust, and weakened bowel sounds. Exudation, anesthesia and other reasons are related. Traditional Chinese medicine believes that this disease is caused by the stagnation of qi movement and obstruction of visceral qi, resulting in the dysfunction of the spleen and stomach.

[0003] Clinically, the drugs used to promote gastrointestinal motility are mainly western medicines such as dopamine receptor antagonists, serotonin receptor agonists and motilin receptor agonists, and most of them have obvious adverse r...

Examples

Embodiment 1

[0033] Weigh 100g of hydroxypropyl-β-cyclodextrin, add it to 500mL of purified water, stir until dissolved; add 200mL Magnolia officinalis Rheum officinalis extract to the above solution, and incubate at 50°C for 1.5 hours; measure wood Citrus aurantium extract 200mL, weigh 3g of adenosine monophosphate, 3g of citric acid, 10g of neotame, 5g of lemon essence and 0.5g of methyl p-hydroxybenzoate, then keep stirring at 70°C for 1.5h; cool to room temperature, Add purified water to dilute to 1000mL.

Embodiment 2

[0035] Weigh 50g of α-cyclodextrin, add it to 500mL of purified water, and stir until dissolved; add 200mL Magnolia officinalis Rhubarb extract to the above solution, and keep warm at 40°C for 2 hours; Cream 200mL, weigh 5g of adenosine monophosphate, 5g of sodium citrate, 5g of neotame, 2g of apple essence and 0.3g of ethyl p-hydroxybenzoate, then keep stirring at 80°C for 1h; cool to room temperature, add purified water to dilute to 1000mL.

Embodiment 3

[0037] Weigh 10g of β-cyclodextrin, add it to 500mL of purified water, stir until dissolved; add 200mL Magnolia officinalis Rhubarb extract to the above solution, and keep warm at 60°C for 0.5 hours; Paste 200mL, weigh 8g of adenosine monophosphate, 10g of sodium starch glycolate, 3g of aspartame, 4g of lemon essence and 0.3g of ethyl p-hydroxybenzoate, then keep stirring at 80°C for 1h; cool to room temperature, add Dilute to 1000mL with purified water.

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a taste-masking method of a magnolia bark exhaust mixture, a magnolia bark exhaust mixture and a preparation method thereof. Background technique

[0002] Decreased gastrointestinal motility after pelvic and abdominal surgery is a common complication after gynecological surgery, manifested as abdominal distension, anorexia, defecation without exhaust, and weakened bowel sounds. Exudation, anesthesia and other reasons are related. Traditional Chinese medicine believes that this disease is caused by the stagnation of qi movement and obstruction of visceral qi, resulting in the dysfunction of the spleen and stomach.

[0003] Clinically, the drugs used to promote gastrointestinal motility are mainly western medicines such as dopamine receptor antagonists, serotonin receptor agonists and motilin receptor agonists, and most of them have obvious adverse r...

Examples

Embodiment 1

[0033] Weigh 100g of hydroxypropyl-β-cyclodextrin, add it to 500mL of purified water, stir until dissolved; add 200mL Magnolia officinalis Rheum officinalis extract to the above solution, and incubate at 50°C for 1.5 hours; measure wood Citrus aurantium extract 200mL, weigh 3g of adenosine monophosphate, 3g of citric acid, 10g of neotame, 5g of lemon essence and 0.5g of methyl p-hydroxybenzoate, then keep stirring at 70°C for 1.5h; cool to room temperature, Add purified water to dilute to 1000mL.

Embodiment 2

[0035] Weigh 50g of α-cyclodextrin, add it to 500mL of purified water, and stir until dissolved; add 200mL Magnolia officinalis Rhubarb extract to the above solution, and keep warm at 40°C for 2 hours; Cream 200mL, weigh 5g of adenosine monophosphate, 5g of sodium citrate, 5g of neotame, 2g of apple essence and 0.3g of ethyl p-hydroxybenzoate, then keep stirring at 80°C for 1h; cool to room temperature, add purified water to dilute to 1000mL.

Embodiment 3

[0037] Weigh 10g of β-cyclodextrin, add it to 500mL of purified water, stir until dissolved; add 200mL Magnolia officinalis Rhubarb extract to the above solution, and keep warm at 60°C for 0.5 hours; Paste 200mL, weigh 8g of adenosine monophosphate, 10g of sodium starch glycolate, 3g of aspartame, 4g of lemon essence and 0.3g of ethyl p-hydroxybenzoate, then keep stirring at 80°C for 1h; cool to room temperature, add Dilute to 1000mL with purified water.