HPLC fingerprint spectrum detection method of fossil fragment oyster bone-strengthening granules
A technology of fingerprints and Longmu Zhuanggu, which is applied in the field of HPLC fingerprint detection of Longmu Zhuanggu Granules, can solve the problems of inability to fully control the quality of traditional Chinese medicine compound, and achieve the effect of convenient operation
Active Publication Date: 2018-01-12
JIANMIN PHARMA GRP CO LTD
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Problems solved by technology
[0005] The purpose of the present invention is to establish a HPLC fingerprint detection method for Longmu Zhuanggu Granules for the defect that the current quality detection method of Longmu Zhuanggu Granules cannot fully control the quality of the compound Chinese medicine
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[0031] The present invention will be described in detail below through specific examples.
[0032] The Longmu Zhuanggu Granules used in the following examples were all prepared according to the method of "Chinese Pharmacopoeia" 2015 edition, provided by Jianmin Pharmaceutical Group Co., Ltd.
[0033] 1. Instruments and reagents
[0034] Dianne P680 high performance liquid chromatography, quaternary pump, online vacuum degassing system, autosampler, column thermostat, UV detector; ME-104E electronic balance (Shanghai Mettler-Toledo Instrument Co., Ltd.).
[0035] 11 batches of Longmu Zhuanggu Granules (batch numbers are 1705125, 1706290, 1706271, 1705211, 1706286, 1610773, 1612741, 1706262, 1612911, 1612738, 1612915, a total of 11 batches); potassium dihydrogen phosphate is analytically pure, and acetonitrile is Chromatographic grade, water is purified water.
[0036] 2. Method steps
[0037] (1) Preparation of the test solution: take Longmu Zhuanggu granules and grind them ...
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Abstract
The invention discloses an HPLC fingerprint spectrum detection method of fossil fragment oyster bone-strengthening granules. A liquid phase fingerprint spectrum measuring condition is established by screening the conditions such as instruments for measuring the fingerprint spectrum, a chromatographic column, a moving phase and detection wavelength, methodological observation is conducted, and thestandard fingerprint spectrum of the fossil fragment oyster bone-strengthening granules is formulated according to multi-batch mass-production products. Feeding can be effectively guided and the production operation can be standardized strictly in the production process through HPLC fingerprint spectrum detection on the fossil fragment oyster bone-strengthening granules, safety, effectiveness andreliability of clinical medication are guaranteed truly, and compared with other detection methods, the method has the advantages of convenience in operation, rapidness and the like.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine detection, and relates to an HPLC fingerprint detection method of Longmu Zhuanggu granules. Background technique [0002] Fingerprint is a comprehensive and quantifiable means of identifying traditional Chinese medicinal materials and preparations. It is mainly used to identify authenticity and evaluate the quality uniformity and stability of raw medicinal materials, semi-finished products and preparations. Compared with the quality analysis method of determining the content of index components, fingerprints can more comprehensively reflect the types and quantities of chemical components of traditional Chinese medicines. Under the current situation that the active ingredients of traditional Chinese medicine compound preparations have not been fully clarified, it can realize the comprehensive evaluation and evaluation of the internal quality of traditional Chinese medicines. The effectiv...
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IPC IPC(8): G01N30/02
Inventor 赵洋李霞黄志军吴木琴赵刚童懿杨颃蔡威
Owner JIANMIN PHARMA GRP CO LTD