Enrofloxacin injection

Abstract

The invention discloses an enrofloxacin injection, which includes, by weight, 2.5-10% of enrofloxacin, 2-10% of nicotinamide, 10-30% of propylene glycol, 0.01-0.05% of EDTA disodium, 0.1-0.5% of an antioxidant, 0.3-1.4% of a pH conditioner, and the balanced being injection water. The enrofloxacin injection solves a technical problem of poor stability at low temperature and enables curative effectsto be fully achieved. The enrofloxacin injection is qualified through detection of quality standard of enrofloxacin injection in Chinese Veterinary Pharmacopoeia (2010 version), is a national standard product and has low formula cost. A preparation method is easy to carry out and is suitable for large-scale production in enterprises.

Description

technical field [0001] The invention relates to an injection, in particular to an enrofloxacin injection. Background technique [0002] Enrofloxacin is a fluoroquinolone antibiotic, which is a broad-spectrum bactericidal drug and is widely used in veterinary clinics. Cocci, etc. have bactericidal effect, and have special effects on mycoplasma. Enrofloxacin is mainly excreted through the kidneys, and its metabolism in animals is mainly to remove the ethyl group to become ciprofloxacin. The biggest feature of this drug is the joint action of enrofloxacin and its metabolite ciprofloxacin in animals , which is also an important reason why this drug is better than other similar drugs and is widely used in animals. [0003] Because enrofloxacin itself has a strong bitter taste, when it is used as an oral dosage form, the tolerated dose of animals is relatively low, so it is generally administered in the form of injection in clinical use. However, the stability of enrofloxacin i...

AI Technical Summary

Problems solved by technology

However, the stability of enrofloxacin injection is poor, especially in low temperature environment, it is easy to precipitate crystals, which seriously affects the curative effect and safety. This is a particularly prominent problem in the cold regions of northern my country. Small

But enrofloxacin is easily soluble in sodium hydroxide solution. Therefore, in the prior art, when preparing enrofloxacin injection, the method of adding sodium hydroxide is mainly adopted to increase the solubility of enrofloxacin in water, but in order to achieve The expected therapeutic effect will increase the concentration of enrofloxacin, resulting in an increase in the amount of sodium hydroxide added, and because the biological environment in the animal body is weakly acidic, if the injection solution with a high pH value is injected, it will be harmful to the body. Animals are more irritating, which is not conducive to the full play of the curative effect of enrofloxacin injection