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Blood lipid level related single nucleotide polymorphism rs4377290 detecting system and related application

A detection system and polymorphism technology, which can be used in the detection/testing of microorganisms, DNA/RNA fragments, recombinant DNA technology, etc., and can solve the problems of lack of research data on Asian populations

Active Publication Date: 2018-02-02
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

However, almost all of these loci were originally identified in populations of European ancestry, and data from studies in Asian populations, especially Chinese populations, are lacking

Method used

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  • Blood lipid level related single nucleotide polymorphism rs4377290 detecting system and related application
  • Blood lipid level related single nucleotide polymorphism rs4377290 detecting system and related application
  • Blood lipid level related single nucleotide polymorphism rs4377290 detecting system and related application

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Embodiment 1

[0024] The present invention is divided into two stages (a preliminary screening stage and a verification stage) to detect and analyze genetic mutations related to TC, LDL-C, HDL-C and TG respectively.

[0025] The study population included 47532 subjects in the first phase and 13,408 subjects in the verification phase. All studies included 61,180 East Asian subjects. Each study was approved by its research institution and the ethics committee of the local investigation institution. All participants signed written informed consent.

[0026] In the first stage, a meta-analysis of the exome association study was carried out on 47,532 subjects in the East Asian population. 47532 study subjects, from China Eye Research (CHES), China Health and Nutrition Survey (CHNS), Fangchenggang Male Health Examination Survey (FAMHES), Guizhou Bijie Type 2 Diabetes Study (GBTDS), Hong Kong University Special Research Project (HKU-TRS) ), Hubei Coronary Heart Disease Research (HuCAD), and China’s A...

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Abstract

The invention provides a blood lipid level related single nucleotide polymorphism rs4377290 detecting system and related application, particularly determines relevance between single nucleotide polymorphism rs4377290 and blood lipid level, provides application of reagent materials and / or instruments for detecting polymorphism of a rs4377290 locus in a sample of a to-be-tested individual to preparation of a detecting system for assessment of blood lipid level and / or dyslipidemia risks, and further provides the detecting system for assessment of the blood lipid level and / or the dyslipidemia risks. The detecting system comprises the reagent materials and / or instruments for detecting polymorphism of the rs4377290 locus in the sample of the to-be-tested individual, wherein rs4377290 is remarkably related to TC level, and rs4377290 locus T allele carriers are higher in total cholesterol level and / or dyslipidemia risks than non-carriers.

Description

Technical field [0001] The present invention relates to a single nucleotide polymorphism rs4377290 detection system related to blood lipid levels and related applications. Specifically, the present invention relates to reagent materials and / or reagent materials for detecting the rs4377290 polymorphism of the CD16 gene in a sample from an individual to be tested. Or the application of equipment in preparing a detection system for assessing blood lipid levels and / or dyslipidemia risk, and also relates to a detection system for assessing blood lipid levels and / or dyslipidemia risk. Background technique [0002] A large number of studies have shown that dyslipidemia is an independent risk factor for coronary heart disease, myocardial infarction, sudden cardiac death and ischemic stroke. It accelerates systemic atherosclerosis, causing insidious, gradual, progressive, systemic and organic damage to the body. Studies have shown that for every 1% increase in the blood cholesterol level...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 顾东风黄建凤鲁向锋李宏帆杨学礼
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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