Small-molecular active peptide and preparation method thereof, and preparation method and application of transdermal patch adopting active peptide

A technology of small molecule active peptides and transdermal patches, which is applied in the preparation of transdermal patches for the treatment of osteoarthritis, small molecule active peptides and their preparation, and in the field of medical patches, which can solve the problems that are difficult to penetrate the surface of the skin. Suitable for external use of drugs, large molecular weight and other issues, to achieve the effect of improving bioavailability and avoiding the first-pass effect

Inactive Publication Date: 2018-02-09
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional protein or peptide drugs are difficult to penetrate through the skin surface bec...

Method used

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  • Small-molecular active peptide and preparation method thereof, and preparation method and application of transdermal patch adopting active peptide
  • Small-molecular active peptide and preparation method thereof, and preparation method and application of transdermal patch adopting active peptide
  • Small-molecular active peptide and preparation method thereof, and preparation method and application of transdermal patch adopting active peptide

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Embodiment Construction

[0022] Preferred embodiments of the present invention are described below, and it should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0023] A preparation method of small molecule active peptide, which comprises the following steps:

[0024] S1. Take 6kg of fresh animal spine or femur, wash, sterilize with ultraviolet light, and crush it through an 8-mesh sieve after drying. Put it in a constant temperature reaction tank with 4kg dried and crushed melon seeds to 20 mesh, add 60L distilled water and stir evenly, add 200g papaya For protease, make the enzyme activity ≥6000U / mg, adjust the pH value to 5.0 with hydrochloric acid, react at 50°C for 12h, centrifuge at 3000rpm / min for 10min, and separate the supernatant;

[0025] S2. After cooling the supernatant to room temperature, place it in a 4°C freezer for 24 hours, separate the degreasing layer,...

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Abstract

The invention belongs to the technical field of biomedicines and in particular discloses a preparation method for preparing a transdermal patch for treating osteoarthritis by utilizing small-molecularactive peptide and novel application. The biological external use type transdermal patch containing the small-molecular active peptide is prepared from the small-molecular active peptide and a hydrogel adhesive; the preparation method of the transdermal patch comprises the following steps: carrying out mixed enzymolysis on fresh animal thigh bones or backbones and muskmelon seeds; carrying out ultrafiltration to obtain supernatant with the molecular weight of 5000 Daltons or lower; uniformly mixing the supernatant with a prepared hydrogel matrix according to a proper ratio and coating and drying to obtain the external use type transdermal patch containing the small-molecular active peptide. The transdermal patch disclosed by the invention has a very good effect of improving degenerative osteoarthritis.

Description

technical field [0001] The invention relates to a medical patch, which belongs to the technical field of medical auxiliary medicines, in particular to a small molecule active peptide and its preparation method, as well as the preparation method of a transdermal patch for treating osteoarthritis using the active peptide and its application . Background technique [0002] Osteoarthritis is a degenerative disease due to bone loss and tissue aging and is the most common chronic, progressive disease after middle age. According to research data, the incidence rate of osteoarthritis in people over 65 years old is more than 50%, and in people over 75 years old, this value can reach about 80%. my country has gradually entered an aging society, and the number of patients with osteoporosis has exceeded 90 million, and there is a trend of further increase. Moreover, a considerable number of patients with the above two diseases mainly suffer from knee joints, lumbar vertebrae, femurs a...

Claims

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Application Information

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IPC IPC(8): C07K2/00C07K14/46C07K14/415C12P21/06A61K38/17A61K38/16A61K38/02A61K9/70A61P19/02A61P19/10
CPCA61K9/7023A61K38/02A61K38/168A61K38/17C07K2/00C07K14/415C07K14/46C12P21/06
Inventor 吴科锋刘义李延平吕应年李立
Owner GUANGDONG MEDICAL UNIV
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