Method for evaluating completeness of mesorectum specimen after colorectal cancer

A technology for colorectal cancer and evaluation methods, applied in the field of medical imaging, can solve problems such as lack of accuracy, and achieve the effect of standardized treatment

Inactive Publication Date: 2018-02-09
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method of visual evaluation is obviously subjective and lacks certain accuracy.

Method used

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  • Method for evaluating completeness of mesorectum specimen after colorectal cancer
  • Method for evaluating completeness of mesorectum specimen after colorectal cancer
  • Method for evaluating completeness of mesorectum specimen after colorectal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] like figure 1 As shown, a method for evaluating the integrity of the mesorectal specimen after colorectal cancer surgery, the method specifically includes the following steps:

[0062] (a) Sample preparation: The mesorectal specimens were separated from the resection specimens after laparoscopic total colectomy / rectal resection, marked to distinguish the front and back of the mesentery, and placed in a -86°C refrigerator for storage as multiphoton imaging specimens to be tested;

[0063] (b) Multiphoton collagen imaging: fix the multiphoton imaging specimen to be tested in step (a), and perform second harmonic imaging on the entire mesorectal sample using a single-channel detector to obtain a multiphoton imaging image, the second harmonic imaging The output power of wave imaging is 1.5W, the imaging wavelength is 800nm, the receiving wavelength is 390nm, the imaging multiple is 10 times, and the imaging area is 1cm×1cm;

[0064] (c) Slice preparation: the reverse side ...

Embodiment 2

[0068] A method for evaluating the integrity of a mesorectal specimen after colorectal cancer surgery, said method specifically comprising the following steps:

[0069] (a) Sample preparation: The mesorectal specimens were separated from the resection specimens after laparoscopic total colectomy / rectal resection, marked to distinguish the front and back of the mesentery, and placed in a -86°C refrigerator for storage as multiphoton imaging specimens to be tested;

[0070] (b) Multiphoton collagen imaging: fix the multiphoton imaging specimen to be tested in step (a), and perform second harmonic imaging on the entire mesorectal sample using a single-channel detector to obtain a multiphoton imaging image, the second harmonic imaging The output power of wave imaging is 1.8W, the imaging wavelength is 820nm, the receiving wavelength is 410nm, the imaging multiple is 10 times, and the imaging area is 1cm×1cm;

[0071] (c) Slice preparation: the reverse side of the mesorectum in the...

Embodiment 3

[0075] A method for evaluating the integrity of a mesorectal specimen after colorectal cancer surgery, said method specifically comprising the following steps:

[0076] (a) Sample preparation: The mesorectal specimens were separated from the resection specimens after laparoscopic total colectomy / rectal resection, marked to distinguish the front and back of the mesentery, and placed in a -86°C refrigerator for storage as multiphoton imaging specimens to be tested;

[0077] (b) Multiphoton collagen imaging: fix the multiphoton imaging specimen to be tested in step (a), and perform second harmonic imaging on the entire mesorectal sample using a single-channel detector to obtain a multiphoton imaging image, the second harmonic imaging The output power of wave imaging is 1.6W, the imaging wavelength is 810nm, the receiving wavelength is 400nm, the imaging multiple is 10 times, and the imaging area is 1cm×1cm;

[0078] (c) Section preparation: the reverse side of the mesorectum in t...

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Abstract

The invention provides a method for evaluating completeness of a mesorectum specimen after colorectal cancer and relates to the technical field of medical imaging. According to the method, the mesorectum specimen after colorectal cancer is subjected to tissue evaluation on the basis of a multi-photon imaging technology in combination with staining sections, wherein the staining sections can be used for macroscopic analysis of gross structure and overall proportion of collagen of the mesorectum; multi-photon imaging can be used for micro-imaging the collagen of the mesorectum and analyzing thefine structure of the collagen; with combination of the two collagen analysis methods, completeness of the mesorectum can be distinguished from the macroscopic level and the microcosmic level, then the problem that the conventional naked eye based evaluation standards have obvious subjectivity and is lack of certain accuracy is solved, a clinical worker can be helped to know whether total mesorectal excision is realized in a colorectal cancer operation, and radical operation for colorectal cancer is more standardized.

Description

technical field [0001] The invention relates to the technical field of medical imaging, in particular to a method for evaluating the integrity of mesorectal specimens after colorectal cancer surgery. Background technique [0002] Colorectal cancer is the third most common malignant tumor in my country, and its incidence has risen rapidly in recent years. In the treatment of colorectal cancer, colorectal resection plays an important role. In 1982, Heald et al. proposed the concept of mesorectum, wrapping around the rectum in the visceral layer of pelvic fascia, which is composed of loose connective tissue, rich in fat, lymph, nerve and vascular tissue, and defined as mesorectum. Based on the anatomical level of rectal cancer surgery, Hohenberger et al. proposed the theory of total mesorectal excision based on the anatomy of rectal cancer surgery. In 2009, Hohenberger et al. proposed for the first time that the fascial structure of the colon and its mesentery is the continuat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/63G01N1/28
CPCG01N1/28G01N21/63
Inventor 严俊李凯徐硕瑀李国新蒋伟刘张苑珠陈德鑫严博韬陈伟生
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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