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Preparation method of cough-relieving and asthma-relieving preparation

A preparation and powder technology, applied in the field of preparation of cough and asthma preparations, can solve the problems of reducing curative effect, acute toxicity, failure to find a method of crushing degree and extraction and purification, etc., and achieve the effect of prolonging the incubation period and being easy to apply and promote

Inactive Publication Date: 2018-02-23
贵州拜特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, researchers believe that excessive crushing of plant cells will cause further dissolution of toxic substances in the cells, and excessive intake may cause acute toxicity; adding water to decoction is a common extraction method for general medicines, but the ingredients are complex, and the active ingredients are wrapped in more More ineffective substances reduce the curative effect
Existing research has not yet found the best method of pulverization and extraction and purification, which can safely and effectively improve the cough and asthma effects of asthma preparations

Method used

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  • Preparation method of cough-relieving and asthma-relieving preparation
  • Preparation method of cough-relieving and asthma-relieving preparation
  • Preparation method of cough-relieving and asthma-relieving preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Preparation of Zhike Dingchuan Capsules

[0055] Prescription: 443g poppy shell, 110g bellflower, 443g ephedra, 66g licorice

[0056] Preparation:

[0057] (1) Get poppy shells, platycodon grandiflorum, ephedra, and licorice to be pulverized into powders with a particle diameter of 4mm respectively, each divided into 2 equal parts, and set aside;

[0058] (2) Take a portion of Platycodon grandiflorum and licorice powder, mix them, soak for 4 hours, add 8BV water to extract 3 times, each time 2 hours, combine the extracts, and set aside.

[0059] (3) Mix a portion of ephedra and poppy shell powder respectively, decoct with an acidic aqueous solution with a pH value of 4, decoct twice, decoct for 2 hours each time, filter and combine the filtrate after decoction, and use a mass fraction of 10 % sodium hydroxide solution to adjust the pH value to be neutral, then mix with the extract of step (2), concentrate to a thick paste with a relative density of 1.30 (60°...

Embodiment 2

[0066] Example 2 Preparation of Zhike Dingchuan Tablets

[0067] Recipe: 500g poppy shell, 160g bellflower, 500g ephedra, 100g licorice

[0068] Preparation:

[0069] (1) Get poppy shells, platycodon grandiflorum, ephedra, and licorice to be pulverized into powders with a particle diameter of 6mm respectively, each divided into 2 equal parts, and set aside;

[0070] (2) Take a portion of Platycodon grandiflorum and licorice powder, mix them, soak for 5 hours, add 10BV water to extract 3 times, each time for 2.5 hours, combine the extracts, and set aside.

[0071] (3) Mix a portion of ephedra and poppy shell powder respectively, decoct with an acidic aqueous solution with a pH value of 6, decoct twice, decoct for 2.5 hours each time, filter and combine the filtrate after decoction, and use a mass fraction of 15 % sodium hydroxide solution to adjust the pH value to be neutral, then mix with the extract of step (2), concentrate to a thick paste with a relative density of 1.30 (...

Embodiment 3

[0078] Example 3 Preparation of Zhike Dingchuan Granules

[0079] Recipe: 400g poppy shell, 70g bellflower, 400g ephedra, 30g licorice

[0080] Preparation:

[0081] (1) Get poppy shells, platycodon grandiflorum, ephedra, and licorice to be pulverized into powders with a particle diameter of 2mm respectively, each divided into 2 equal parts, and set aside;

[0082] (2) Take a portion of Platycodon grandiflorum and licorice powder, mix them, soak for 3 hours, add 5BV water to extract twice, each time for 1.5 hours, combine the extracts, and set aside.

[0083] (3) Mix a portion of ephedra and poppy shell powder respectively, decoct with an acidic aqueous solution with a pH value of 2, decoct twice, decoct for 1.5 hours each time, filter and combine the filtrate after decoction, and use a mass fraction of 5 % sodium hydroxide solution to adjust the pH value to be neutral, then mix with the extract of step (2), concentrate to a thick paste with a relative density of 1.30 (60°C)...

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Abstract

The invention discloses a preparation method of a cough-relieving and asthma-relieving preparation, and belongs to the technical field of a traditional Chinese medicine preparation. The cough-relieving and asthma-relieving preparation is prepared from ephedra, pericarpium papaveris, platycodon grandiflorum, liquorice and excipients. According to the major function of am anti-asthma capsule, the type and property of effective components are defined, one part of four medicinal materials in a prescription is crushed into ultra-fine powder, the other part of four medicinal materials is extracted,and then the extract liquid and ultra-micro powder are mixed to prepare the preparation. The preparation method obtain effective substances in each traditional Chinese medicine to the utmost extent, amethod for mixing powder and the extract liquid is adopted, the asthma incubation period of an experimental asthma animal is prolonged, the cough and asthma treatment effects of the cough-relieving and asthma-relieving preparation are obviously stronger than that of a traditional asthma capsule. The preparation is non-toxic and stable, and the preparation process is easy to operate and industrialapplication can be achieved.

Description

technical field [0001] The invention relates to a preparation method of an antitussive and antiasthmatic preparation, belonging to the technical field of medicine. Background technique [0002] Bronchial asthma (bronchial asthma, referred to as asthma, also known as allergic asthma) is one of the most common chronic respiratory diseases in the world today. etc.) and cell components involved in airway chronic inflammatory diseases, which can cause extensive reversible airflow limitation, causing clinical symptoms such as paroxysmal wheezing, shortness of breath, chest tightness, chest pain or cough. [0003] In the literature of traditional Chinese medicine, asthma belongs to the category of "wheezing", "roaring", and coughing in traditional Chinese medicine. The discussion about asthma in relevant books on traditional Chinese medicine first appeared in the "Huangdi Neijing". "There is "autumn pulse...if it is not enough, it will make people pant, and if you have less breath...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P11/14A61P11/06
CPCA61K36/17A61K36/346A61K36/484A61K36/66A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 薛捷张禄权田紫平李白玲班腾敏蒋禹章
Owner 贵州拜特制药有限公司