Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of cytotoxic active spider peptide to research and development of anti-tumor medicine

An anti-tumor drug and cytotoxic technology, applied in the direction of anti-tumor drugs, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of low selectivity of anti-cancer drugs, public health threats to cancer patients, and high side effects. Addresses low selectivity and high side effects, strong anti-cancer migration activity, and pain-relieving effects

Active Publication Date: 2018-02-27
HUNAN NORMAL UNIVERSITY
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The low selectivity and high side effects of various anticancer drugs used in clinical practice have posed a serious threat to the public health of the world for cancer patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cytotoxic active spider peptide to research and development of anti-tumor medicine
  • Application of cytotoxic active spider peptide to research and development of anti-tumor medicine
  • Application of cytotoxic active spider peptide to research and development of anti-tumor medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] In order to reveal the anti-cancer and anti-migration effects of LVTX-VIII, we detected the inhibitory properties of LVTX-VIII on A549 and H460 different lung cancer cells at the cell level and animal level, and carried out statistics and analysis on its related indicators. The experiments were carried out in strict accordance with the standards of clinical and standardization institutes.

[0026] 1. Main materials and instruments

[0027] Reagents related to cell culture were purchased from Thermo Fisher Corporation, and other reagents related to cell experiments were produced by themselves. A549 and H460 cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences. Transwell migration and invasion chambers were purchased from Corning Corporation. Nude mice were purchased from Slack Theta.

[0028] 2. Experimental methods and results

[0029] 2.1 In vitro anticancer and anti-migratory activities of LVTX-VIII

[0030] A549, H460 and HEK293T c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses application of cytotoxic active spider peptide to research and development of an anti-tumor medicine. Linear peptide with strong cytotoxic activity, which is designed and synthesized from CDNA of Lycosa vittata, is applied to the research and the development of the anti-tumor medicine. The anti-cancer peptide is active polypeptide toxin designed from the CDNA of the Lycosavittata, contains 25 amino acid residues, has the molecular weight of 2849.50 Da, has the isoelectric point of 10.6, and adopts an amino acid sequence as follows: Ile Trp Leu Thr Ala Leu Lys Phe Leu Gly Lys Asn Leu Gly Lys His Leu Ala Lys Gln Gln Leu Ser Lys Leu.

Description

technical field [0001] The invention belongs to the technical field of polypeptide drugs in biochemistry, in particular to a kind of Lycosa vittata Application of anticancer peptides obtained from spider cDNA in antitumor drugs. Background technique [0002] The low selectivity and high side effects of a variety of anticancer drugs used in clinical practice have posed a serious threat to the public health of the world for cancer patients. Therefore, it is very urgent to develop a drug with selectivity and small side effects and has become a difficult problem to be solved urgently. In terms of developing new anticancer drugs, the high selectivity and high activity exhibited by antimicrobial peptides (ACPs) were once considered to be a powerful new weapon against various cancers. Due to the different composition of the cancer cell membrane and the normal cell membrane, it has a certain selectivity, and its mechanism of action is diverse, killing cancer cells quickly, not l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/17A61P35/00A61P35/04
CPCA61K38/1767
Inventor 刘中华梁宋平张鹏
Owner HUNAN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com