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Tofacitinib analogues

A compound and pharmaceutical technology, applied in the field of tofacitinib analogs, can solve problems such as inability to apply, adverse reactions, etc., and achieve a significant therapeutic effect

Inactive Publication Date: 2018-03-09
WUXI FORTUNE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still some patients who do not respond to these drugs, or cannot be used due to adverse reactions

Method used

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Embodiment Construction

[0019] The present invention will be described in detail below in conjunction with various embodiments, but it should be noted that these embodiments are not limitations of the present invention, and those of ordinary skill in the art can make functional, method, or structural equivalent transformations or replacements based on these embodiments. , all fall within the protection scope of the present invention.

[0020] Unless otherwise specified, the term "room temperature" in each embodiment of this specification is specifically 23°C; the term "h" is specifically the unit of time measurement: hour; the term "min" is specifically the unit of time measurement: minute; the term "ml" is specifically the unit of measurement for time: The unit of volume: milliliter; the term "L" specifically refers to the unit of volume: liter; the term "mol / L" specifically refers to the unit of concentration. The term "mmol" is specifically the unit of the amount of a substance, ie millimole; the ...

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Abstract

The present invention provides tofacitinib analogues. The analogues contain a compound represented by a formula (I) in the description or a pharmaceutically-acceptable salt of the compound. The invention also discloses a pharmaceutical composition containing the compound represented by the formula I and an application.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a tofacitinib analogue. Background technique [0002] Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease characterized by joint synovitis and symmetrical and destructive joint lesions. The research on the pathogenesis and treatment of RA has been in continuous development. Many studies have tried to find therapeutic opportunities from different channels such as intracellular signal transduction pathways and cytokines, and have made some progress. For example, methotrexate (MTX) has achieved good results in the treatment of RA since its clinical application in 1980; the first biological agent (TNF inhibitor) targeting tumor necrosis factor (TNF) mainly interferes with T cells, B Cells and other immune cell receptors and inflammatory cytokines) was used in the treatment of RA in 2000, which is a new milestone. Since more and more RA patients are not sensitive ...

Claims

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Application Information

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IPC IPC(8): C07D519/00A61K31/519A61P37/06A61P29/00A61P19/02
Inventor 王涛王彬彬王庆林孙益林游本加曹娜
Owner WUXI FORTUNE PHARMA
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