Biomimetic collagen bone repair material with multilayer structure and preparation method thereof

A collagen bone and repair material technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as inability to achieve bone structure, single structure, and low mechanical strength

Active Publication Date: 2020-10-27
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult for bone repair materials with a single structure to achieve bone biomimesis.
Nano-hydroxyapatite / collagen composite materials are currently common bone repair materials, but most of them have a single structure and cannot achieve bionic bone structure
In addition, because hydroxyapatite is not easy to disperse, it is difficult to form an effective connection with collagen
Furthermore, the mechanical strength of traditional hydroxyapatite-collagen materials is still low, which is not enough to meet the requirements of bone repair materials

Method used

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  • Biomimetic collagen bone repair material with multilayer structure and preparation method thereof
  • Biomimetic collagen bone repair material with multilayer structure and preparation method thereof
  • Biomimetic collagen bone repair material with multilayer structure and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Embodiment one, a kind of preparation method of the biomimetic collagen bone repair material with multi-layer structure, is characterized in that:

[0040] (1) Take a certain quality of pigskin-derived type I collagen, single-layer graphene oxide solids, and nano-hydroxyapatite solids and dissolve them in 0.1mol / L acetic acid solution, and use an ultrasonic probe to assist stirring for 30 minutes in an ice bath , the conditions of the ultrasonic stirring are: the power is 180w, the stirring intensity is 20-50%, and the content of type I collagen is 3wt%, the content of nano-hydroxyapatite is 3wt%, and the content of graphene oxide is 0.2wt%. The homogeneous A solution;

[0041] (2) Take a certain quality of type I collagen, single-layer graphene oxide solid, and nano-hydroxyapatite solid and dissolve them in 0.1mol / L acetic acid solution, and use an ultrasonic probe to assist stirring for 30 minutes in an ice bath, and the ultrasonic stirring The conditions are: the po...

Embodiment 2

[0047] Embodiment two, a kind of preparation method of biomimetic collagen bone repair material with multilayer structure, is characterized in that:

[0048] (1) Take a certain amount of source type I collagen, single-layer graphene oxide solid and nano-hydroxyapatite solid and dissolve them in 0.1mol / L acetic acid solution, and use an ultrasonic probe to assist stirring for 30min under an ice bath. The conditions of ultrasonic stirring are: the power is 180w, the stirring intensity is 50%, and the content of type I collagen is 2wt%, the content of nano-hydroxyapatite is 2wt%, and the content of graphene oxide is 0.2wt%. solution;

[0049] (2) Take a certain quality of type I collagen, single-layer graphene oxide solid, and nano-hydroxyapatite solid and dissolve them in 0.1mol / L acetic acid solution, and use an ultrasonic probe to assist stirring for 30 minutes in an ice bath, and the ultrasonic stirring The conditions are: the power is 180w, the stirring intensity is 50%, an...

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Abstract

The invention provides a bionic collagen bone repair material with a multi-layer structure and a preparation method thereof. The bone repair material is composed of a three-layer structure of a cortical bone layer, an intermediate layer and a cancellous bone layer from top to bottom. The cortical bone layer is formed by pouring an acetic acid solution containing 2-3wt% type I collagen, 2-3wt% graphene oxide and 0.2-0.3wt% nano-hydroxyapatite into a mold and freeze-drying; the middle The layer is formed by pouring an acetic acid solution containing 1-2wt% type I collagen, 1-2wt% graphene oxide and 0.1-0.2wt% nano-hydroxyapatite into a mold and then freeze-drying; the cancellous bone layer is formed by containing 0.5 The acetic acid solution of ~1wt% type I collagen and 0.5~1wt% nanometer hydroxyl phosphorus is poured into the mold and freeze-dried to form. The invention has a multi-layer structure, can be applied to bone defects of different depths, can speed up the bone repair process, and can be customized according to the depth and range of clinical bone defects.

Description

technical field [0001] The invention relates to the field of artificial bone repair materials, in particular to a biomimetic collagen bone repair material with a multi-layer structure composed of nano-hydroxyapatite-graphene oxide-collagen and a preparation method thereof. Background technique [0002] So far, the repair of large bone defects caused by trauma, infection and tumor resection has been a long-standing problem in clinical medicine at home and abroad. Autologous bone sources are limited, and patients may need to bear additional pain. Other bone repair materials, such as allogeneic bone or xenograft bone, are prone to problems such as potential infection and immune rejection. There are still many deficiencies in artificial bone due to its large structure difference from natural bone. Therefore, artificial bone repair materials can greatly improve their application value in terms of composition and structure. [0003] Collagen is a protein synthesized and secrete...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/40A61L27/56
CPCA61L27/446A61L27/46A61L27/56A61L2430/02
Inventor 刘绍恺孙家明汪振星牟珊陈雳风周牧冉曾宇阳李嘉伦周楚超罗超黎媛侯金飞方慧敏
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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