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Application of orientin in preparation of drugs used for treating atherosclerosis

A technology for atherosclerosis and atherosclerosis in rats, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem that there are no preventive measures and therapeutic drugs, and the etiology and pathogenesis have not been fully elucidated. And other issues

Inactive Publication Date: 2018-04-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs

Method used

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  • Application of orientin in preparation of drugs used for treating atherosclerosis
  • Application of orientin in preparation of drugs used for treating atherosclerosis
  • Application of orientin in preparation of drugs used for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of compound Orientin tablet involved in the present invention:

[0017] Take 5 grams of compound Orientin, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0018] Embodiment 2: the preparation of the compound Orientin capsule involved in the present invention:

[0019] Take 5 grams of compound Orientin, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

[0021] The present invention reveals the effect of Orientin on atherosclerosis through cell level research and establishment of atherosclerosis model.

[0022] The present invention gives Orientin by oral and intravenous injection, which can significantly reduce plaque area / intima area (%), intima thickness (um) / media thickness (%) in atherosclerotic rats; Ester, total cholesterol and low-density lipoprotein content decreased, indicating that Orientin can treat atherosclerosis.

[0023] Materials and Methods

[0024] 1. Experimental materials:

[0025] 1.1 Animals and feed

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Abstract

The invention relates to the application of Orientin in the preparation of drugs for treating atherosclerosis. Orientin can play an anti-atherosclerotic effect by regulating blood lipids and protecting endothelial cells. The anti-atherosclerosis drug prepared by using Orientin has good curative effect on atherosclerosis, and can be used to resist human or animal atherosclerosis. The use of Orientin involved in the present invention in the preparation of anti-atherosclerotic drugs is disclosed for the first time. Since the skeleton type is a brand-new skeleton type, and its inhibitory activity on atherosclerosis is unexpectedly strong, there is no such thing as given by other compounds. Possibility of any enlightenment, with outstanding substantive features, while being used for anti-atherosclerosis is obviously a significant progress.

Description

technical field [0001] The present invention relates to a new application of compound Orientin, in particular to the application of Orientin in the preparation of drugs for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. [0003] The compound Orientin involved in the present invention is a new compound published in 2013 (Ebenezer de Mello Cruz, et al., Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement. Phytochemistry, 89 (2013) 71...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/48A61K9/20A61P9/10
CPCA61K31/7048A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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