Non-solvated crystals as well as preparation method and application thereof

A non-solvated, crystal technology, applied in the direction of organic chemical methods, non-central analgesics, anti-inflammatory agents, etc., can solve the problem of not preparing non-solvated crystals, etc.
CN107868044AActive Publication Date: 2018-04-03SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD
Publication Date
2018-04-03

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Abstract

The invention relates to non-solvated crystals A, B and C of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxo)-1-naphthalene amide and a preparation method of non-solvated crystals A, B and C, also relates to pharmaceutical composition containing the crystals and an application of the crystals in preparation of a drug for treating diseases related to abnormal activities of protein kinase or abnormalactivities of histone deacetylase.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to non-solvated crystals of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxygen)-1-naphthylcarboxamide and a preparation method thereof and application. Background technique

[0002] N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxo)-1-naphthylcarboxamide is a dual-target inhibitor of protein kinase and histone deacetylase. The chemical structure is shown in structural formula (I).

[0003]

[0004] In the Chinese patent application CN200910223861.5, the pharmacological activity of the compound of formula (I) is described. This compound has protein kinase inhibitory activity and histone deacetylase inhibitory activity, and can be used for the treatment of abnormal protein kinase activity and histone deacetylation Diseases associated with abnormal enzyme activity, including inflammation, autoimmune diseases, cancer, neurological and neurodegenerative diseases, cardiovascular diseases...

Claims

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