Isoalantolactone derivatives and their application in preparation of drugs for treating inflammatory bowel diseases are provided, and an isoalantolactone derivative shown as in formula (I) is provided; a salt-forming acid is an inorganic acid or organic acid, the inorganic acid is selected from hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid, bromic acid, seleninic acid, phosphomolybdic acid, phosphorus acid and sulfurous acid, and the organic acid is selected from citric acid, maleic acid, D-malic acid, L-malic acid, DL-malic acid, L-lactic acid, D-lactic acid, DL-acid, oxalic acid, methylsulfonic acid, pentanoic acid, oleic acid, lauric acid, p-methylbenzene sulfonic acid, 1-naphthalene sulfonic acid, 2-naphthalene sulfonic acid, phthalic acid, tartaric acid, malonic acid, succinic acid, fumaric acid, glycolic acid, mercapturic acid, glycine, creatine, sulfonic acid, nicotinic acid, picolimic acid, isonicotinic acid, and benzoic acid or substituted benzoic acid.