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heatr4 gene as a biomarker for the diagnosis of osteoporosis

An osteoporosis and gene technology, applied in biological testing, disease diagnosis, biomaterial analysis, etc., can solve the problems that osteoporosis patients cannot be screened, and achieve early diagnosis, genetic diagnosis, and genetic diagnosis immediate effect

Active Publication Date: 2019-01-04
BEIJING MEDINTELL BIOMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The objects of auxiliary examination are generally patients with advanced osteoporosis, and cannot be used for the screening of patients with early osteoporosis

Method used

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  • heatr4 gene as a biomarker for the diagnosis of osteoporosis
  • heatr4 gene as a biomarker for the diagnosis of osteoporosis
  • heatr4 gene as a biomarker for the diagnosis of osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 Screening of genes differentially expressed in patients with osteoporosis and normal people

[0056] 1. Research object:

[0057] Osteoporosis group: randomly select 10 patients with primary osteoporosis admitted to the orthopedics department of the hospital, 5 males and 5 females, the youngest is 50 years old and the oldest is 75 years old. Inclusion criteria: in line with the "Recommended Diagnostic Criteria for Osteoporosis in China" (Second Draft). No obvious heart, liver, kidney, pulmonary insufficiency, no various endocrine diseases causing secondary osteoporosis, no tumor, diabetes and other serious diseases that interfere with bone metabolism.

[0058] Normal group: select 10 healthy volunteers aged 50-75, 5 males and 5 males.

[0059] There was no significant difference in age and gender between the two groups (P>0.10), which were comparable.

[0060] All research subjects were informed about this study and signed the informed consent.

[0061] 2....

Embodiment 2

[0079] Embodiment 2QPCR experiment verification of genes differentially expressed in patients with osteoporosis and normal people

[0080] 1. Research object:

[0081] Osteoporosis group: randomly select 50 patients with primary osteoporosis admitted to the orthopedics department of the hospital, 25 males and 25 females, the youngest is 50 years old and the oldest is 75 years old. Inclusion criteria: in line with the "Recommended Diagnostic Criteria for Osteoporosis in China" (Second Draft). No obvious heart, liver, kidney, pulmonary insufficiency, no various endocrine diseases causing secondary osteoporosis, no tumor, diabetes and other serious diseases that interfere with bone metabolism.

[0082] Normal group: 46 healthy volunteers aged 50-75 were selected, 23 males and 23 males.

[0083] There was no significant difference in age and gender between the two groups (P>0.10), which were comparable.

[0084] All research subjects were informed about this study and signed th...

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Abstract

The invention discloses a HEATR4 gene used as a biomarker for early diagnosing osteoporosis. A detection method is characterized by firstly detecting expression condition of differential genes in small sample research objects through high-throughput sequencing, and then verifying differentially-expressed genes in large samples by using QPCR. The research results show that the detection method is capable of judging whether the subjects suffer from osteoporosis by detecting the expression condition of the HEATR4 gene in the blood; the detection method can be used for early diagnosing osteoporosis and has the characteristics of timeliness and accuracy.

Description

technical field [0001] The invention belongs to the field of molecular diagnosis, and relates to a molecular marker for diagnosing osteoporosis, in particular to the application of the molecular marker-HEATR4 gene in blood in the preparation of products for diagnosing osteoporosis. Background technique [0002] Osteoporosis (osteoporosis, OP) is a group of bone diseases caused by a variety of reasons. There is normal calcification in bone tissue, and the ratio of calcium salt to matrix is ​​normal. It is a metabolic bone disease characterized by a decrease in the amount of bone tissue per unit volume. . In most cases of osteoporosis, the loss of bone tissue is mainly due to increased bone resorption. Characterized by bone pain and susceptibility to fractures. [0003] The World Health Organization has listed osteoporosis as the second largest disease that endangers human health after cardiovascular disease. According to the latest "2013 China Osteoporotic Fracture Prevent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883C12Q2600/158G01N33/6893G01N2333/47G01N2800/108
Inventor 肖枫李曙光孙耀兰常鹏
Owner BEIJING MEDINTELL BIOMED CO LTD