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Nano composite hydrogel as well as preparation method application thereof

一种纳米复合、水凝胶的技术，应用在水凝胶领域，能够解决限制应用、明胶差机械性能等问题，达到分布均匀、价格低廉、粒径小的效果

Active Publication Date: 2018-04-17
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor mechanical properties of gelatin limit its application.

Method used

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  • Nano composite hydrogel as well as preparation method application thereof
  • Nano composite hydrogel as well as preparation method application thereof
  • Nano composite hydrogel as well as preparation method application thereof

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preparation example Construction

[0034] The invention provides a kind of preparation method of nanocomposite hydrogel, comprises the following steps:

[0035] (1) gelatinizing short amylose;

[0036] (2) Mix the gelatinized short amylose with an aqueous gelatin solution with a mass concentration of 8%-14%, and cool to obtain a nanocomposite hydrogel.

[0037] The present invention has no special limitation on the source of short amylose, which can be commercially available or self-prepared. If adopt self-prepared mode, the preparation method of described short amylose preferably comprises the following steps:

[0038] ① Mix the waxy cornstarch solution with disodium hydrogen phosphate-citric acid buffer solution, and gelatinize in a boiling water bath to obtain a gelatinized product;

[0039] ②According to the enzyme dosage of 3-5u / g, mix the gelatinized product with pullulanase, and enzymolyze it at 50-60°C for 6-10h;

[0040] ③ inactivate the enzymatic hydrolyzate obtained in step ②;

[0041] ④ Mix the ...

Embodiment 1

[0068] (1) The preparation method of short amylose, comprises the steps:

[0069] ①Weigh 6g of waxy cornstarch, add 100ml of disodium hydrogen phosphate-citric acid buffer solution distilled water, and prepare a starch solution with a concentration of 6%;

[0070] ② After adjusting the pH of the starch solution to 4.6 with disodium hydrogen phosphate-citric acid buffer solution, heat it in a water bath for 30 minutes under boiling water bath conditions;

[0071] ③Add pullulanase and react for 8 hours in a constant temperature water bath at 58°C;

[0072] ④Inactivate the enzyme in a boiling water bath for 15 minutes;

[0073] ⑤ Add 4 times the volume of absolute ethanol, and centrifuge to remove the supernatant to obtain a solid precipitate; then wash 2-3 times with water, freeze-dry in a freeze dryer, and the condition parameters for freeze-drying are: temperature -86°C, pressure 20Pa , time 48h; short amylose was obtained after freeze-drying.

[0074] (2) The preparation m...

Embodiment 2

[0080] (1) The preparation method of short amylose, comprises the steps:

[0081] ①Weigh 6g of waxy cornstarch, add 100ml of disodium hydrogen phosphate-citric acid buffer solution distilled water, and prepare a starch solution with a concentration of 6%;

[0082] ② After adjusting the pH of the starch solution to 4.6 with disodium hydrogen phosphate-citric acid buffer solution, heat it in a water bath for 30 minutes under boiling water bath conditions;

[0083] ③Add pullulanase and react for 8 hours in a constant temperature water bath at 58°C;

[0084] ④Inactivate the enzyme in a boiling water bath for 15 minutes;

[0085] ⑤ Add 4 times the volume of absolute ethanol, and centrifuge to remove the supernatant to obtain a solid precipitate; then wash 2-3 times with water, freeze-dry in a freeze dryer, and the condition parameters for freeze-drying are: temperature -86°C, pressure 20Pa , time 48h; short amylose was obtained after freeze-drying.

[0086] (2) The preparation m...

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Abstract

The invention provides nano composite hydrogel and a preparation method thereof and relates to the field of nano composite materials. The nano composite hydrogel is prepared through the steps of mixing completely gelatinized short amylose and a gelatin water solution with the mass concentration of 8 percent to 14 percent and cooling. According to the nano composite hydrogel provided by the invention, nanoparticles formed by self-assembling the short amylose in the gelatin water solution in situ are used as a reinforcing agent; the nanoparticles are uniformly distributed in the hydrogel to forma stable crystallization system, so that the prepared nano composite hydrogel has good mechanical properties in the aspects of viscoelasticity, rigidity, compression stress and the like. The nano composite hydrogel and the preparation method thereof have the advantages that a preparation process is environmentally friendly, simple and efficient and can be widely applied to the fields of foods, cosmetics and medicines.

Description

technical field [0001] The invention relates to the field of hydrogels, in particular to a nanocomposite hydrogel and its preparation method and application. Background technique [0002] Natural hydrogels are three-dimensional biopolymeric networks that can absorb and maintain large amounts of water, and have potential applications in food, cosmetics, and biomedicine due to their biodegradability, biocompatibility, and renewability. . [0003] Hydrogels need to have high strength and flexibility when applied, as well as reversible deformation properties. However, ordinary chemically crosslinked polymer hydrogels are brittle under certain pressure. The following approaches have been attempted to enhance the mechanical properties of hydrogels, including crosslinked hydrogels, double network hydrogels and nanocomposite hydrogels. Among these methods, the preparation method of nanocomposite hydrogels is simple, so it has attracted much attention. [0004] Simple mixing of n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L3/12C08L89/00C08B30/20C08B30/12
CPCC08B30/12C08B30/20C08J3/075C08J2303/12C08J2207/10C08J2489/00C08J2403/12C08J2389/00C08L3/12C08L89/06C08J2489/06C08J2389/06C12P19/14C08J2205/022C08J2201/048C08J9/28C08J2207/00C08J9/0061C08J2205/06C12P19/16
Inventor 孙庆杰熊柳葛胜菊卢浩李曼赵梅
Owner QINGDAO AGRI UNIV