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A preparation method of special artificial skin for burns

A technology of artificial skin and preparation steps, applied in the direction of prosthesis, medical science, etc., can solve the problems of poor healing effect and sterilization effect of artificial skin, achieve good humidity control effect, avoid polar kidney failure, and induce cell growth. Effect

Inactive Publication Date: 2021-01-12
范娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main technical problem to be solved by the present invention is to provide a method for preparing artificial skin for burns in view of the poor healing effect and bactericidal effect of traditional artificial skin

Method used

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  • A preparation method of special artificial skin for burns

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Effect test

example 1

[0026]Pour the sepiolite into a pulverizer, pass through a 500-mesh sieve after crushing to obtain sepiolite powder, then mix and soak the obtained sepiolite powder and 10% hydrochloric acid at a mass ratio of 1:10 for 6 hours, filter to obtain filtered Cake, and the obtained filter cake was dried to constant weight at a temperature of 110°C to obtain dry sepiolite powder, and the obtained dried sepiolite powder was transferred to a tube furnace, and roasted at a temperature of 280°C for 5 hours, followed by Cool to room temperature and discharge to obtain pretreated sepiolite; mix chitosan and water into No. 1 beaker according to the mass ratio of 1:15, stir and mix with a glass rod for 15 minutes, and then stand at room temperature to swell 5h, after the swelling is over, add chitosan enzyme with 8% chitosan mass to the No. 1 beaker, and move the No. 1 beaker into a digital speed measuring constant temperature magnetic stirrer at a temperature of 40°C and a speed of 500r / min ...

example 2

[0028] Pour the sepiolite into a pulverizer, pass through a 500-mesh sieve after crushing to obtain sepiolite powder, then mix and soak the obtained sepiolite powder and 10% hydrochloric acid at a mass ratio of 1:10 for 6 hours, filter to obtain filtered Cake, and the obtained filter cake was dried to constant weight at a temperature of 110°C to obtain dry sepiolite powder, and the obtained dried sepiolite powder was transferred to a tube furnace, and roasted at a temperature of 280°C for 5 hours, followed by Cool to room temperature and discharge to obtain pretreated sepiolite; in parts by weight, 10 parts of polyethylene glycol, 10 parts of bacterial cellulose, 0.8 part of glycerin, 200 parts of mass fraction are 5% dilute acetic acid solution, First pour polyethylene glycol, bacterial cellulose and glycerin into a mortar, grind and mix for 20 minutes, then pour the ground material into a No. 2 beaker filled with dilute acetic acid solution, stir and mix with a glass rod for ...

example 3

[0030] Pour the sepiolite into a pulverizer, pass through a 500-mesh sieve after crushing to obtain sepiolite powder, then mix and soak the obtained sepiolite powder and 10% hydrochloric acid at a mass ratio of 1:10 for 6 hours, filter to obtain filtered Cake, and the obtained filter cake was dried to constant weight at a temperature of 110°C to obtain dry sepiolite powder, and the obtained dried sepiolite powder was transferred to a tube furnace, and roasted at a temperature of 280°C for 5 hours, followed by Cool to room temperature and discharge to obtain pretreated sepiolite; mix chitosan and water into No. 1 beaker according to the mass ratio of 1:15, stir and mix with a glass rod for 15 minutes, and then stand at room temperature to swell 5h, after the swelling is over, add chitosan enzyme with 8% chitosan mass to the No. 1 beaker, and move the No. 1 beaker into a digital speed measuring constant temperature magnetic stirrer at a temperature of 40°C and a speed of 500r / min...

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Abstract

The invention discloses a method for making special artificial skin for burning, belonging to the technical field of medical material preparation. The method comprises the following steps: firstly, mixing and swelling chitosan with water, performing enzymolysis so as to obtain chitosan enzymolysis liquid, further moistening polyethylene glycol and bacterial cellulose with glycerinum, dispersing into a diluted acetic acid solution so as to obtain a mixed dispersion, mixing the chitosan enzymolysis liquid with the dispersion, onion juice, a Carbomer dispersion, nano silver powder, sesame oil, plant essential oil, a biomass surfactant, pretreated sepiolite and aids, and performing high-speed shearing so as to obtain a filming emulsion; and further marking two surfaces of the lower epidermis of a plant leaf, spraying a dopamine solution to one surface, standing, further coating so as to obtain a filming emulsion, drying at low temperature till an appointed water content is achieved, spraying a metallic salt solution, further performing constant-temperature and constant-wet standing, and performing sterilization, drying and packaging, thereby obtaining the special artificial skin for burning. The special artificial skin for burning, which is disclosed by the invention, is excellent in healing effect and sterilization effect.

Description

technical field [0001] The invention discloses a method for preparing an artificial skin specially used for burns, and belongs to the technical field of medical material preparation. Background technique [0002] Artificial skin is a skin substitute artificially developed in vitro by using the principles and methods of engineering and cell biology. It is used to repair and replace defective skin tissue. According to different components, it can be divided into pure artificial dermis and those with epidermal cell layer activity. Composite leather. [0003] The skin not only protects a person from dirt or bacteria, but also keeps moisture from escaping from the body. When a large area of ​​skin is severely burned or damaged, doctors must immediately infuse fluids and protect the wound. If only a superficial layer of skin is damaged, new skin will regenerate. If a patient has suffered a severe burn, the skin cannot repair itself, and superficial skin from another part of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/02A61L27/04A61L27/16A61L27/18A61L27/20A61L27/36A61L27/54A61L27/60
CPCA61L27/025A61L27/047A61L27/16A61L27/18A61L27/20A61L27/3637A61L27/54A61L27/60A61L2300/104A61L2300/30A61L2300/404A61L2300/412C08L1/02C08L5/08C08L71/02C08L33/02
Inventor 范娟陈加宏陈兴权许博伟张淼
Owner 范娟
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