Analysis method of key proteins and clinical relations of liver cancer

A key protein and relationship analysis technology, applied in the fields of gene transcriptomics and proteomics, can solve the problems that the precision and accuracy cannot meet the analysis requirements and affect the quantitative detection of low-abundance proteins, etc.

Inactive Publication Date: 2018-04-20
南宁科城汇信息科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The high sensitivity of mass spectrometry can help people discover low-abundance proteins and peptides in biological samples in the stage of marker discovery. The dynamic range greatly affects the quantitative detection of low-abundance proteins and peptides in biological fluids by mass spectrometry
Although researchers have tried to use a var

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] Consists of the following steps:

[0022] Through bioinformatics analysis, analyze the functions of the finally screened key protein polypeptides of liver cancer; through the absolute quantitative verification of large sample MRM, calculate the sensitivity, specificity, positive predictive value and negative predictive value of the key protein polypeptides of liver cancer in the diagnosis of liver cancer, and compare with Correlation analysis of different clinical pathological types, different course of disease, primary and metastasis, curative effect of liver cancer, etc., to propose their clinical application feasibility in prevention, early diagnosis, disease course prediction and prognosis judgment of liver cancer;

[0023] ①Retrieve the key protein interactions through IntACT, Reactome, ConsensusPathDB, LOMA, The Human Protein Reference Database, human protein-protein interaction prediction database and other databases, use Pajek, cytoscape and other software to con...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for analyzing the relationship between liver cancer key proteins and clinical conditions. The function of the finally screened liver cancer key protein polypeptides is analyzed through bioinformatics analysis; Sensitivity, specificity, positive predictive value and negative predictive value, as well as the correlation analysis with different pathological types, different course of disease, primary and metastasis, and curative effect of liver cancer, and put forward their role in the prevention, early diagnosis, disease course prediction and prognosis judgment of liver cancer. Feasibility of clinical application; liver cancer is the first cancer killer in Guangxi. It is of great significance to find effective tumor markers for the study of carcinogenesis mechanism, early diagnosis and prognosis of the disease.

Description

technical field [0001] The invention relates to the fields of gene transcriptomics and proteomics, in particular to a method for analyzing the relationship between key liver cancer proteins and clinical trials. Background technique [0002] In the 20th century, primary liver cancer has risen to become the second cancer killer in my country, second only to lung cancer in urban areas and gastric cancer in rural areas [1] . At present, about 35,000 people in Guangxi die of malignant tumors every year, among which, about 12,000 people die of liver cancer. It can be seen that liver cancer is the first cancer killer in Guangxi. In Guangxi, the hazards of liver cancer are very uneven. The counties and cities with high mortality rate of liver cancer are mainly concentrated in the southwestern part of Guangxi. The three counties of Fusui, Long'an and Wuming around Nanning have the highest incidence. The incidence density of liver cancer in this local area reaches 50-60 / 100,000. In...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N33/574
CPCG01N33/57438G01N33/57484
Inventor 于思创王海云
Owner 南宁科城汇信息科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap