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A kind of preparation method of short prismatic α-calcium sulfate hemihydrate powder

A technology of calcium sulfate hemihydrate and calcium sulfate dihydrate, applied in chemical instruments and methods, calcium/strontium/barium sulfate, calcium/strontium/barium compounds, etc., can solve the problem of difficult to provide mechanical strength and biological activity of bone repair parts. Weakness, poor mechanical properties and other problems, to achieve the effect of easy industrial production, easy process control, high compressive strength

Active Publication Date: 2019-11-15
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the currently clinically used calcium sulfate bone graft material has coarse crystal grains, usually ranging from tens to tens of microns, and its morphology is mainly needle-like and plate-like, and its degradation rate is faster than the growth rate of new bone tissue. The performance is poor, it is difficult to provide the mechanical strength required by the bone repair site, and the biological activity is weak and other defects

Method used

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  • A kind of preparation method of short prismatic α-calcium sulfate hemihydrate powder
  • A kind of preparation method of short prismatic α-calcium sulfate hemihydrate powder
  • A kind of preparation method of short prismatic α-calcium sulfate hemihydrate powder

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Embodiment 1

[0051] A preparation method of short prismatic α-calcium sulfate hemihydrate powder, the steps are as follows:

[0052] Prepare 2mol / L Ca(NO 3 ) 2 ethanol solution and (NH 4 ) 2 SO 4 Aqueous solution, Ca(NO 3 ) 2 Alcohol / water volume ratio in the ethanol solution is 1:1; Open the external circulation rotating packed bed, adjust the rotating speed to 2500rpm; Open the feed pump, the Ca(NO 3 ) 2 ethanol solution and (NH 4 ) 2 SO 4 The aqueous solution is simultaneously transported to the external circulation rotating packed bed for crystallization reaction, the feeding rate of the two salt solutions is controlled at 550mL / min, and the temperature of the reaction system is controlled at 25°C; after the crystallization reaction is completed, the rotating packed bed is closed, and the generated precursor slurry is The materials were filtered, washed, and dried to obtain the precursor powder; 1g of citric acid and 5g of aluminum nitrate were dissolved in 500mL of deionized...

Embodiment 2

[0056] A preparation method of short prismatic α-calcium sulfate hemihydrate powder, the steps are as follows:

[0057] Prepare 2mol / L Ca(NO 3 ) 2 ethanol solution and (NH 4 ) 2 SO 4 Aqueous solution, Ca(NO 3 ) 2 Alcohol / water volume ratio in the ethanol solution is 1:1; Open the external circulation rotating packed bed, adjust the rotating speed to 2500rpm; Open the feed pump, the Ca(NO 3 ) 2 ethanol solution and (NH 4 ) 2 SO 4 The aqueous solution is simultaneously transported to the external circulation rotating packed bed for crystallization reaction, the feeding rate of the two salt solutions is controlled at 550mL / min, and the temperature of the reaction system is controlled at 25°C; after the crystallization reaction is completed, the rotating packed bed is closed, and the generated precursor slurry is The materials were filtered, washed, and dried to obtain the precursor powder; 0.025g of citric acid was dissolved in 500mL of deionized water, dissolved in ult...

Embodiment 3

[0061] A preparation method of short prismatic α-calcium sulfate hemihydrate powder, the steps are as follows:

[0062] Prepare 2mol / L Ca(NO 3 ) 2 ethanol solution and (NH 4 ) 2 SO 4 Aqueous solution, Ca(NO 3 ) 2 Alcohol / water volume ratio in the ethanol solution is 1:1; Open the external circulation rotating packed bed, adjust the rotating speed to 2500rpm; Open the feed pump, the Ca(NO 3 ) 2 ethanol solution and (NH 4 ) 2 SO 4 The aqueous solution is simultaneously transported to the external circulation rotating packed bed for crystallization reaction, the feeding rate of the two salt solutions is controlled at 550mL / min, and the temperature of the reaction system is controlled at 25°C; after the crystallization reaction is completed, the rotating packed bed is closed, and the generated precursor slurry is The materials were filtered, washed, and dried to obtain the precursor powder; 0.6g of succinic acid was dissolved in 500mL of deionized water, dissolved in ult...

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Abstract

The invention discloses a preparation method for short-prism-like alpha-calcium sulfate hemihydrate powder. The preparation method comprises the following steps: adding a calcium salt-ethanol solutionand a sulfate-water solution into an outer-circulation rotary packed bed, and carrying out a reaction at 20 to 60 DEG C so as to obtain a calcium sulfate dihydrate precursor suspension; subjecting the suspension to pumping filtration, washing and drying so as to obtain a calcium sulfate dihydrate precursor; adding the obtained calcium sulfate dihydrate precursor into a reaction solution with a temperature of 80 to 120 DEG C and a pH value of 2 to 8 for a constant-temperature reaction of 4 to 12 h, and carrying out reflux condensation during the reaction; and filtering a reaction product whilethe reaction product is still hot, washing the reaction product with hot water, terminating hydration by using ethanol, and then carrying out rapid pumping filtration and drying so as to obtain the alpha-calcium sulfate hemihydrate powder. The preparation method is simple in process, mild in condition, low in cost, easy to control and scale up, and convenient for industrial production.

Description

technical field [0001] The invention relates to the technical field of biomedical materials. More specifically, it relates to a preparation method of short prismatic α-calcium sulfate hemihydrate powder. Background technique [0002] The repair and reconstruction of bone defects caused by trauma, infection, tumor or bone disease has always been an important research direction in the fields of orthopedics and plastic surgery. The traditional method uses autologous bone or allogeneic bone for graft repair, but the source is limited, there are problems such as virus transmission, immune rejection, etc., and it is difficult to meet the needs of use, thus prompting artificial bone repair materials such as calcium phosphate, calcium sulfate, and acrylic extensive research and application. Among numerous inorganic bone materials, α-calcium sulfate hemihydrate has been recognized by scholars and doctors for its degradability, good biocompatibility and excellent osteoconductivity. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01F11/46
CPCC01F11/46C01F11/466C01P2004/03C01P2004/61C01P2006/80
Inventor 陈建峰张咏青王洁欣乐园曾晓飞
Owner BEIJING UNIV OF CHEM TECH
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