A quadruple stimuli-responsive polyamino acid nanogel and its preparation method and application
A technology of polyamino acid and nanogel, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, aerosol delivery, etc., can solve the problems of restricted application range, complicated preparation process, and limited application fields, and achieve good results. The effect of biocompatibility and chirality, simple preparation process, and clear chemical structure
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Embodiment 1
[0049] Weigh 9.5 g of polyethylene glycol monomethyl ether methacrylate (equivalent to 10 mmol), 44.2 mg of chain transfer agent cyanoisopropyl dithiobenzoate (equivalent to 0.2 mmol), and 1.64 mg of initiator AIBN (equivalent to 0.01 mmol) was placed in a 50ml single-necked bottle, and 10 mL of toluene was added to dissolve it. After 15 minutes of deoxygenation with nitrogen gas, it was heated to 70°C for 2 hours, and precipitated with petroleum ether to obtain polymethacrylic acid polyethylene glycol monomethyl ether Ester (macromolecular chain transfer agent CTA-1) 4.7 g. The weight-average molecular weight of gained poly(ethylene glycol monomethyl ether) methacrylate M w = 24940 g / mol, number average molecular weight M n = 23750 g / mol, degree of polymerization n=25.
[0050] weigh N -Acryloyl-Glycine-L-Leucine- N,N -Dimethylaminoacetamide (monomer A-1) 3.8 g (equivalent to 12 mmol), poly(ethylene glycol monomethyl ether methacrylate) (macromolecular chain transfer a...
Embodiment 2
[0053] 1. Preparation of quadruple stimuli-responsive polyamino acid nanogels
[0054] Weigh 9.9 g of N,N-dimethylacrylamide (equivalent to 100 mmol), 808 mg of 4-cyano-4-[[(dodecylthio)thionemethyl]thio]valeric acid (equivalent to 2 mmol), AIBN 66 mg (equivalent to 0.4 mmol) were placed in a 50 ml single-necked bottle, dissolved in 10 mL of tetrahydrofuran, deoxygenated by nitrogen gas for 15 min, then heated to 65 °C for 3 h, and precipitated with ether to obtain polyN, N-dimethylacrylamide (macromolecular chain transfer agent CTA-2) 7.8 g. The weight-average molecular weight of the polyN,N-dimethylacrylamide obtained M w = 4320 g / mol, number average molecular weight M n = 4000 g / mol, degree of polymerization n=39.
[0055] Weigh methacryloyl-L-alanine- N,N Diethylacetamide (monomer B-1) 3.83 g (equivalent to 15 mmol), poly N,N-dimethylacrylamide (macromolecular chain transfer agent CTA-2) 1.2 g (equivalent to 0.3 mmol), Azodicyanovaleric acid 28 mg (equivalent to 0....
Embodiment 3
[0071] Weigh 2.0 g of 4-cyano-4-[[(dodecylthio)thionemethyl]thio]valeric acid (equivalent to 5 mmol), polyethylene glycol monomethyl ether (average molecular weight 2000 g / mol) 4.0 g (equivalent to 2 mmol), 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride 0.48 g (equivalent to 2.5 mmol) were placed in a 50 ml single-necked bottle, and no Dissolve 10 mL of dichloromethane in water, and react at room temperature for 24 hours under nitrogen protection. After the reaction, add 90 mL of dichloromethane, extract and separate layers, take the organic phase and wash with 0.1 M HCl aqueous solution, saturated sodium bicarbonate aqueous solution, and saturated brine, respectively, 80 mL. Dry the organic phase with anhydrous magnesium sulfate, filter, take the filtrate and evaporate to remove the organic solvent to obtain 4-cyano-4-[[(dodecylthio)thionemethyl]thio]valeric acid polyethylene glycol Monomethyl ether ester (macromolecular chain transfer agent CTA-3) 5.6 g.
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