Method for separating asiatic toddalia root-bark petroleum ether extract with HSCCC

A technology of petroleum ether extract and 300 rods, which is applied in the field of HSCCC separation of 300 rods of petroleum ether extracts, can solve the problems of small monomer types and quantities, unsatisfactory results, poor repeatability, etc., and achieve time-consuming and time-consuming solutions. High force, rich variety of monomers, high repeatability effect

Active Publication Date: 2018-05-18
HUBEI UNIV FOR NATITIES
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Problems solved by technology

[0003] To sum up, the problems existing in the prior art are: the separation and purification of the traditional three-hundred-bar compound is mainly obtained by traditional column chromatography or preparative chromatography, and the traditional separation and purification method is time-consuming and la...

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  • Method for separating asiatic toddalia root-bark petroleum ether extract with HSCCC
  • Method for separating asiatic toddalia root-bark petroleum ether extract with HSCCC
  • Method for separating asiatic toddalia root-bark petroleum ether extract with HSCCC

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Embodiment Construction

[0019] In order to further understand the content, features and effects of the present invention, the following examples are given, and detailed descriptions are given below with reference to the accompanying drawings.

[0020] The structure of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0021] Such as figure 1 As shown, the method for separating three hundred sticks of petroleum ether extracts with HSCCC provided by the embodiments of the present invention comprises the following steps:

[0022] S101: drying three hundred sticks of stem bark to constant weight, and then crushing it to 100 mesh;

[0023] S102: Condensate and reflux the obtained stem bark dry powder of Sanbai, and centrifuge to obtain ethanol extract of Sanbai;

[0024] S103: concentrating and extracting the extract to obtain a petroleum ether extract, concentrating with a rotary evaporator and evaporating to dryness to precipitate a light yellow co...

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Abstract

The invention belongs to the technical field of compound extraction and discloses a method for separating an asiatic toddalia root-bark petroleum ether extract with HSCCC. The method comprises the following steps: drying asiatic toddalia root-bark to a constant weight and then crushing to 100 meshes; performing reflux condensation and centrifugal treatment on obtained asiatic toddalia root-bark dry powder to obtain an asiatic toddalia root-bark ethanol extract; concentrating and extracting the extract to obtain the petroleum ether extract, condensing and drying with a rotary evaporator and separating out a light yellow compound; separating and purifying the light yellow compound and manually collecting all components, wherein a solvent system is n-hexane-ethyl acetate-methanol-water; drying the components collected in the previous step with nitrogen and weighing to respectively obtain a monomer I and a monomer II. The separation and purification method provided by the invention has thebeneficial effects that the separation and the purification of an active monomer in the asiatic toddalia root-bark petroleum ether extract are quickly and efficiently realized, the problem that a traditional separation and purification method is time and labor-consuming is solved, the repeatability is high, and the monomers obtained in a single experiment are rich in species.

Description

technical field [0001] The invention belongs to the technical field of compound extraction, and in particular relates to a method for separating three hundred bar petroleum ether extracts with HSCCC. Background technique [0002] Sanbaibang, also known as Jianxuefei, Dajiujia, etc., is the root and root bark of Rutaceae Pterodactyl. It is mainly produced in Hunan, Hubei, Guizhou, Sichuan and other places, and is distributed in eastern Africa and southeastern and southern Asia. Related literature reports that Feilongzhang blood has good hemostatic and coagulation, analgesic, anti-inflammatory, antibacterial and antiviral activities. Studies have shown that the main chemical components of Sanbaizhu are coumarin, alkaloids, triterpenes, flavonoids, phenols, lignans, steroids and fatty acids. At present, the separation and purification of three hundred bar compounds are mainly obtained by traditional column chromatography technology or preparative chromatography, such as macrop...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61K125/00
CPCA61K36/75A61K2236/15A61K2236/17A61K2236/333A61K2236/50A61K2236/55
Inventor 袁林田瑞向阳夏燕冯佳杨年安李厚聪涂星
Owner HUBEI UNIV FOR NATITIES
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