A preparation method of a mesoporous metal-organic framework nanomaterial with adjustable particle size and the nanomaterial obtained therefrom

Abstract

The invention relates to a preparation method of a particle size adjustable mesoporous metal organic framework nanomaterial, which comprises the steps of dissolving zirconium tetrachloride and monoacid in a solvent, adding a dicarboxylic acid ligand and organic base for reaction to form a mesoporous metal organic framework precursor, taking a zirconia cluster provided by zirconium tetrachloride asa node, allowing monoacid and the dicarboxylic acid ligand to perform competition coordination with zirconium tetrachloride to form the zirconia cluster, allowing the dicarboxylic acid ligand to be coordinated with zirconium tetrachloride to serve as a connector of a metal organic framework, inserting monoacid into hole channels of the metal organic framework via a coordination bond, dispersing the mesoporous metal organic framework precursor in a mixed solution of the solvent and inorganic acid to remove monoacid to form the particle size adjustable mesoporous metal organic framework nanomaterial, wherein inorganic acid damages the coordination bond between monoacid and zirconium tetrachloride. The preparation method is simple in technology and good in reproducibility; the prepared mesoporous metal organic framework nanomaterial is adjustable in particle size, uniform in dimension and good in dispersity.

Description

technical field [0001] The invention relates to the field of nano and biological materials, in particular to a method for preparing a mesoporous metal-organic framework nano material with adjustable particle size and the nano material obtained therefrom. Background technique [0002] In the past few decades, nanotechnology has achieved rapid development in biological and biomedical applications (Angew. Chem. Int. Ed. 2014, 53, 12320-12364; ACS Nano 2012, 6, 1251-1259). Metal-organic frameworks are composed of organic ligands and metal ions connected by coordination bonds, becoming a rapidly developing and emerging porous nanomaterial (J.Am.Chem.Soc.2016,138,962-968; Adv.Funct.Mater .2016, 26, 3244-3249). Compared with traditional nanomaterials, since they can exhibit both hydrophilic and hydrophobic properties, and have tunable pore size and connectivity, they are suitable for drug loading with different physicochemical properties and their medical applications. In additio...

AI Technical Summary

Problems solved by technology

However, there are few reports on nano-MOF carrier materials for macromolecular drug delivery. Recently, it was reported that large-sized biomolecules were directly coated on the surface of metal-organic frameworks instead of being adsorbed into the pores.

However, low adsorption capacity and volatile enzyme activity also limit their application in the field of biomolecule transport

This is because the existing metal-organic framework drug carrier materials often only have a microporous pore structure, and this micropore-sized pore structure can usually only load small molecule drugs, and cannot achieve efficient loading of protein molecules.

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