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Gadolinium-doped monolayer hydrotalcite used for drug loading, preparation method thereof, anti-cancer drug and preparation method thereof

A hydrotalcite and single-layer technology, applied in the field of biomedical materials, can solve the problems of low drug loading and affecting the efficacy of anticancer drugs

Active Publication Date: 2018-06-08
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing drug carrier systems include graphene nanocarriers or transition metal sulfide nanocarriers, but there is a problem of low drug loading, which in turn affects the performance of anticancer drugs

Method used

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  • Gadolinium-doped monolayer hydrotalcite used for drug loading, preparation method thereof, anti-cancer drug and preparation method thereof
  • Gadolinium-doped monolayer hydrotalcite used for drug loading, preparation method thereof, anti-cancer drug and preparation method thereof
  • Gadolinium-doped monolayer hydrotalcite used for drug loading, preparation method thereof, anti-cancer drug and preparation method thereof

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preparation example Construction

[0047] The invention provides a preparation method of gadolinium-doped monolayer hydrotalcite for drug loading, comprising the following steps:

[0048] (1) provide an aqueous inorganic salt solution; the inorganic salts include soluble inorganic magnesium salts, soluble inorganic aluminum salts and soluble inorganic gadolinium salts;

[0049] providing an aqueous solution comprising sodium nitrate and formamide;

[0050] Provide sodium hydroxide aqueous solution;

[0051](2) adding an aqueous inorganic salt solution and an aqueous sodium hydroxide solution in the step (1) to an aqueous solution comprising sodium nitrate and formamide to obtain a raw material mixture;

[0052] (3) Co-precipitate the raw material mixed solution obtained in the step (2) to obtain a solid-liquid mixture;

[0053] (4) The solid-liquid mixture obtained in the step (3) is sequentially separated and the solid product is washed to obtain a gadolinium-doped monolayer hydrotalcite.

[0054] The prese...

Embodiment 1

[0083] Mg(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O and Gd(NO 3 ) 3 ·6H 2 O is weighed according to the molar ratio 2:0.95:0.05, where Mg(NO 3 ) 2 ·6H 2 O is 0.4 mmol, which is dissolved in 40 mL of twice-distilled water to obtain an inorganic salt solution as solution A.

[0084] Weigh 0.2mmol NaNO 3 , and dissolved in twice-distilled water containing 25% formamide by volume as solution B.

[0085] Weigh 4.5 mmol of NaOH and dissolve it in 30 mL of water for later use to obtain a sodium hydroxide solution as solution C.

[0086] Add solution A and solution C dropwise to solution B within 20 minutes until the pH of the solution is 9-10, and then stir for about 30 minutes in an oil bath at 80°C after the dropwise addition. After the reaction, the solution is taken out by separation. The solid was centrifuged and washed three times with deionized water, and the excess formamide was further removed with a dialysis membrane to obtain Gd-doped monolayer hydrotalcite (MLDH)....

Embodiment 2

[0090] Dissolve DOX in PBS, and add 0.01mol / L NaOH solution to adjust the pH value to 8-9, protonate DOX, and add it to Example 1 according to the mass ratio of unprotonated DOX and MLDH of 2:1 The prepared MLDH was stirred at room temperature for 6 h, and then the solid was centrifuged and washed with deionized water for 3 times by separating the solution to obtain DOX-loaded hydrotalcite on the surface. As an anticancer drug, it was recorded as DOX / MLDH.

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Abstract

The invention provides a gadolinium-doped monolayer hydrotalcite used for drug loading and a preparation method thereof. The control for crystal form is realized by adopting sodium nitrate, the control for the thickness of a synthetic hydrotalcite nanosheet is realized through formamide, the monolayer hydrotalcite with the thickness of about 1 nm is obtained, the specific surface area of the gadolinium-doped monolayer hydrotalcite is improved, and then the surface loading capacity of the gadolinium-doped monolayer hydrotalcite as a drug carrier is improved, so that the pesticide effect is improved. The invention also provides the application of the gadolinium-doped monolayer hydrotalcite in the preparation of anti-cancer drugs. By adopting the gadolinium-doped monolayer hydrotalcite provided by the invention as the drug carrier, the loading capacity of the drug reaches up to 790% to 799% at most, and the pesticide effect can be improved obviously. The anti-cancer drug provided by the invention is a nanometer composite material obtained by loading active ingredients of the drug onto the gadolinium-doped monolayer hydrotalcite; and the active ingredients of the drug comprise adriamycin and / or indocyanine green.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a gadolinium-doped single-layer hydrotalcite for drug loading and a preparation method thereof, an anticancer drug and a preparation method thereof. Background technique [0002] Cancer has always been one of the major diseases that are difficult for humans to overcome. The number of deaths due to cancer is gradually increasing every year, and the age of onset of cancer patients is decreasing year by year, which makes early diagnosis and treatment of cancer very important. [0003] Traditional cancer treatment methods mainly include chemical drug therapy, radiation therapy and surgical treatment. These single treatment methods often bring about great side effects, and the treatment effect is not satisfactory. Because traditional treatment methods have certain side effects, scientists tend to have less side effects and minimally invasive treatment methods. Photother...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K31/704A61K31/409A61P35/00
CPCA61K31/409A61K31/704A61K47/02
Inventor 梁瑞政彭刘琪梅旭安卫敏
Owner BEIJING UNIV OF CHEM TECH
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