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Simultaneous estimation of respiratory mechanics and patient effort via parametric optimization

A parametric, respiratory muscle technology, applied in the respiratory field, can solve problems such as interference with the mechanical ventilation mode of treatment

Active Publication Date: 2018-06-08
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this is an invasive technique that interferes with the therapeutic mode of mechanical ventilation that provides the patient with life-sustaining breaths

Method used

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  • Simultaneous estimation of respiratory mechanics and patient effort via parametric optimization
  • Simultaneous estimation of respiratory mechanics and patient effort via parametric optimization
  • Simultaneous estimation of respiratory mechanics and patient effort via parametric optimization

Examples

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Embodiment Construction

[0021] In the methods disclosed herein, the respiratory muscle pressure P mus (t), respiratory system resistance R rs and respiratory compliance C rs or Elastic E rs =1 / C rs Simultaneously estimated on a breath-by-breath basis by the formula for evaluating lung motion:

[0022]

[0023] Among them, P aw (t) is the measured airway pressure, is the measured airway flow, V(t) is the volume of air breathed, that is and P 基线 is a constant. In performing this simultaneous estimation, the airway pressure P aw (t) and airway flow is sampled. Evaluating N samples requires N+2 unknowns (including N P mus The value of (t) and R rs and C rs value) to solve. This is an underdetermined problem because the number of data points (N) is less than the number of unknowns (N+2).

[0024] In addition to the fact that the problem is underdetermined, another challenge recognized in this paper is that the measured airway pressure P aw (t) and airway flow Can be noisy, especial...

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Abstract

Respiratory variables are estimated on a per-breath basis from airway pressure and flow data acquired by airway pressure and flow sensors (20, 22). A breath detector (28) detects a breath interval. Aper-breath respiratory variables estimator (30) fits the airway pressure and flow data over the detected breath interval to an equation of motion of the lungs relating airway pressure, airway flow, and a single-breath parameterized respiratory muscle pressure profile (40, 42) to generate optimized parameter values for the single-breath parameterized respiratory muscle pressure profile. Respiratorymuscle pressure is estimated as a function of time over the detected breath interval as the single-breath parameterized respiratory muscle pressure profile with the optimized parameter values, and may for example be displayed as a trend line on a display device (26, 36) or integrated (32) to generate Work of Breathing (WoB) for use in adjusting settings of a ventilator (10).

Description

technical field [0001] The following generally relates to the field of respiration, the field of respiration monitoring, and related fields such as the field of mechanical ventilation. Background technique [0002] Clinical assessment of the respiratory system can be performed on a quantitative basis by estimating certain respiratory values ​​such as respiratory muscle pressure, respiratory system resistance, and respiratory system compliance or elasticity. [0003] Usually expressed as P mus The respiratory muscle pressure of (t) is the (negative) pressure exerted by the patient during breathing. More specifically, during inspiration, the diaphragm works to expand the volume of the lungs, thus reducing the pressure for a given volume of air (as in the case of blocked airways) or drawing air into the lungs (as in the case of normal inspiration in the case of). Respiratory muscle pressure is generally a useful measure for respiratory monitoring because it is a measure of t...

Claims

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Application Information

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IPC IPC(8): A61B5/087A61B5/03A61B5/085A61B5/091G16H20/40
CPCA61B5/038A61B5/085A61B5/087A61B5/091A61B5/682A61B2505/03G16H50/50G16H40/63G16H50/20G16H20/40A61B5/0816A61B5/7242A61B5/7275
Inventor F·比卡里奥A·阿尔巴内塞王东N·卡拉莫列赫科斯N·W·什巴特
Owner KONINKLJIJKE PHILIPS NV
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