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Neutron target for boron neutron capture therapy

A neutron and neutron source technology, applied in the field of neutron targets for boron neutron capture therapy, can solve problems such as inability to adequately handle high power and target damage

Active Publication Date: 2018-06-08
中子医疗股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the main challenge of this technique is that conventional target structures cannot adequately handle the high power imparted to the target by the proton beam, resulting in significant damage to the target

Method used

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  • Neutron target for boron neutron capture therapy
  • Neutron target for boron neutron capture therapy
  • Neutron target for boron neutron capture therapy

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Embodiment approach

[0099] above for 7 Li(p,n)→ 7 Be's system can be extended to other neutron-generating reactions using other neutron-generating materials. In addition to the "nearthreshold" approach on lithium using a 1.9 MeV proton beam and the "superthreshold" approach using a 2.5 MeV proton beam, other methods that have been proposed for BNCT include: 9 Be(p,n), using a 1.5MeV deuterium beam 9 Be(d,n), and using a 1.5MeV deuterium beam 13 C(d,n). To take advantage of these reactions, solid beryllium sheets can be thermally bonded to the flaps instead of lithium and bombarded with 4 MeV protons or 1.5 MeV deuterium. In addition, lithium can be replaced by graphite or carbon flakes to 13 The C(d,n) reaction produces neutrons.

[0100] A system of the present disclosure may include a rotatable structure, such as a platform or table, on which a neutron source material is disposed and configured to direct a beam of protons toward the neutron source material on the rotatable structure as th...

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Abstract

Apparatuses and methods for producing neutrons for applications such as boron neutron capture therapy (BNCT) are described. An apparatus can include a rotary fixture with a coolant inlet and a coolantoutlet, and a plurality of neutron-producing segments. Each neutron- producing segment of the plurality of neutron-producing segments is removably coupled to the rotary fixture, and includes a substrate having a coolant channel circuit defined therein and a solid neutron source layer disposed thereon. The coolant channel circuits are in fluid communication with the coolant inlet and the coolant outlet.

Description

[0001] related application [0002] This application claims the filing date benefit of US Provisional Patent Application No. 62 / 157,652, filed May 6, 2015, the contents of which are hereby incorporated by reference in their entirety. field of invention [0003] The present disclosure relates to methods and systems for generating neutrons using neutron source materials. Background technique [0004] Neutron sources have a variety of potential uses, including drug therapy, isotope production, detection of explosive / fissionable materials, analysis of precious metal ores, imaging, and more. An area of ​​particular interest is boron neutron capture therapy (BNCT), a cancer treatment technique in which boron is preferentially concentrated in a patient's malignancy and a neutron beam is targeted at the boron-containing tumor through the patient. When a boron atom captures a neutron, the energy of the resulting particle is sufficient to cause severe damage to the tissue in which it...

Claims

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Application Information

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IPC IPC(8): A61N5/10H05H6/00G21G1/10G21G4/02
CPCA61N5/10G21G4/02H05H6/00A61N2005/109G21G1/10A61N2005/1087A61N5/1077H05H3/06G21K5/10G21K5/08
Inventor 小W.H.帕克S.P.科尼什T.H.斯米克T.萨卡斯
Owner 中子医疗股份有限公司
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