Methoxamine hydrochloride injection and preparation method thereof

A technology of methoxamine hydrochloride and injection, applied in chemical instruments and methods, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as weak electrical properties, achieve high tensile strength, improve filtration efficiency, The effect of increasing the specific surface area

Active Publication Date: 2018-06-15
GUANGDONG JIABO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microporous filter membrane prepared by this method has weak electrical properties

Method used

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  • Methoxamine hydrochloride injection and preparation method thereof
  • Methoxamine hydrochloride injection and preparation method thereof
  • Methoxamine hydrochloride injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the preparation method of nano-titanium dioxide-calcium alginate charged microporous membrane

[0031] Including the following steps:

[0032] Use a polysulfone filter membrane with a pore size of 0.22 μm as a carrier, immerse it in concentrated sulfuric acid for 1.5 hours, then rinse it with deionized water, immerse it in nano-titanium dioxide-calcium alginate sol for 15 minutes, rinse it with deionized water, and use it after drying. Calcium chloride aqueous solution with a mass fraction of 2.5% was used as a cross-linking agent, and the cross-linking time was 30 minutes. The charged microporous filter membrane of nano titanium dioxide-calcium alginate is obtained.

[0033] Among them, the nano-titanium dioxide-calcium alginate sol is prepared according to the following steps: take 100mL butyl titanate and dissolve it in 100mL absolute ethanol at room temperature to form a solution A; add another 50mL absolute ethanol to 300mL deionized water, and then ...

Embodiment 2

[0034] Embodiment 2, a kind of methoxamine hydrochloride injection

[0035] The methoxamine hydrochloride injection consists of methoxamine hydrochloride, sodium chloride, hydrochloric acid and water for injection, and every 1000ml of the injection contains 5g methoxamine hydrochloride, 0.5g sodium chloride, and hydrochloric acid to adjust the injection pH to 3.0, the balance is water for injection.

[0036] The preparation method of this methoxamine hydrochloride injection comprises the following steps:

[0037] S1 Take 80% of the water for injection in the formula quantity, add methoxamine hydrochloride and sodium chloride, stir until completely dissolved; obtain mixed solution I;

[0038] S2 adjust the pH of the mixed solution I to 3.0 with hydrochloric acid, add the remaining amount of water for injection, and stir for 30 minutes;

[0039] S3 adjusts the pH of the mixed solution obtained through step S2 with hydrochloric acid to be 3.0, and then filters through the nano-ti...

Embodiment 3

[0044] Embodiment 3, a kind of methoxamine hydrochloride injection

[0045] The methoxamine hydrochloride injection is composed of methoxamine hydrochloride, sodium chloride, hydrochloric acid and water for injection, and every 1000ml of the injection contains 10g of methoxamine hydrochloride, 1g of sodium chloride, and hydrochloric acid to regulate the pH of the injection. To 4.0, the balance is water for injection.

[0046] The preparation method of this methoxamine hydrochloride injection comprises the following steps:

[0047] S1 Take 90% of the water for injection in the formula amount, add methoxamine hydrochloride and sodium chloride, stir until completely dissolved; obtain mixed solution I;

[0048] S2 adjust the pH of the mixed solution I to 4.0 with hydrochloric acid, add the remaining amount of water for injection, and stir for 30 minutes;

[0049] S3 uses hydrochloric acid to adjust the pH of the mixed solution obtained in step S2 to be 4.0, and then filter throu...

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Abstract

The invention discloses methoxamine hydrochloride injection and a preparation method thereof. The methoxamine hydrochloride injection per 1000ml comprises the following components: 5-12g of methoxamine hydrochloride, 0.5-1.2g of sodium chloride, and the balance of injection water, wherein the pH of the injection is adjusted to be 3.0-4.5 with hydrochloric acid. The preparation method of the injection comprises the following steps: preparing a methoxamine hydrochloride solution; stirring until the methoxamine hydrochloride solution is completely dissolved; adjusting the pH of the solution through hydrochloric acid; filtering with a nano titanium dioxide-calcium alginate charged microporous membrane until the solution is clear; filling; sterilizing; detecting leakage; inspecting with light;packing. With the adoption of the method, the fine particle reject rate can be increased, so that the injection filtering effect can be improved; a product is not absorbed; moreover, the pyrogen can be removed, so that the endotoxin of the product meets the regulation; the time for preparation can be shortened; the step of heating is eliminated, and thus methoxamine hydrochloride cannot be degraded; in addition, the technical operation is simple; the production cost is reduced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a methoxamine hydrochloride injection and a preparation method thereof. Background technique [0002] Methoxamine Hydrochloride chemical name: α-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride, molecular formula C 11 h 17 NO 3 ·HCl is an α-adrenergic receptor agonist, which has obvious vasoconstriction effect. It can increase both systolic and diastolic blood pressure by increasing peripheral resistance, so it has no exciting effect on the heart. It is used to treat hypotension that occurs during general anesthesia, and to prevent the occurrence of arrhythmia; it can also be used for hypotension induced by intraspinal block, but it may reduce cardiac output; it can also be used to terminate arrhythmia Onset of supraventricular tachycardia. [0003] Methoxamine hydrochloride is easily soluble in water, and its injection is commonly used in clinical treatment...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/137A61K47/02A61P9/02B01D71/74B01D67/00
CPCA61K9/0019A61K9/08A61K31/137A61K47/02B01D67/0006B01D71/74
Inventor 彭创业曾少群李庆岳峰
Owner GUANGDONG JIABO PHARM CO LTD
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