Pressure sore removing cream prepared from total flavonoids of populus tomentosa leaf and preparation method of pressure sore removing cream

A preparation process and technology of Populus tomentosa, applied in the directions of ointment delivery, emulsion delivery, medical preparations containing active ingredients, etc., can solve the problems of no in-depth research and development, many adverse reactions, and insignificant curative effects, and achieve low drug costs. , good therapeutic effect, fast onset effect

Inactive Publication Date: 2018-06-22
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The background technology shows that although the existing antibacterial drugs and biofilm preparations have certain curative effects on the treatment of pressure sores, the curative effect is not significant, and there are many adverse reactions; Carrying out in-depth research and de

Method used

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  • Pressure sore removing cream prepared from total flavonoids of populus tomentosa leaf and preparation method of pressure sore removing cream
  • Pressure sore removing cream prepared from total flavonoids of populus tomentosa leaf and preparation method of pressure sore removing cream
  • Pressure sore removing cream prepared from total flavonoids of populus tomentosa leaf and preparation method of pressure sore removing cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation process of Populus tomentosa leaf total flavonoids, comprising the steps of:

[0043] SA1. Extraction: Take the leaves of Populus tomentosa, crush them, add 10 times the amount of 70% ethanol solution, heat and reflux for extraction for 3 times, each time for 1.5 hours; combine the extracts, and concentrate under reduced pressure to 50 Each ml of the concentrated solution is equivalent to 1g of the crude drug liquid extract by heat measurement at ℃, and the crude extract of Populus tomentosa leaves is obtained, which is stored in cold storage for later use.

[0044] SA2. Separation of D101 macroporous adsorption resin: take twice the amount of D101 macroporous adsorption resin loaded into the chromatography column, rinse with 95% ethanol until the eluent is clear, and then rinse with distilled water until there is no alcohol smell; slowly drip Add the sample, the dripping speed is 0.5 times the column volume / h, stop washing after the sample is loaded, and ...

Embodiment 2

[0071] On the basis of Example 1, a cream prepared by processing the total flavonoids of Populus tomentosa leaves obtained in Example 1 by adding a base meeting the medicinal requirements.

[0072] A pressure sore cream with total flavonoids from poplar leaves, which is prepared by mixing total flavonoids from leaves of poplar tomentosa and a cream base in the following proportions by weight: 2.0 g total flavonoids from leaves of poplar tomentosa, 15.0 g water, and 1.25 g glycerin , 3.0 g of stearic acid, 0.25 g of petrolatum, 1.25 g of lanolin, 1.33 g of liquid paraffin, 0.9 g of glyceryl monostearate, and 0.1 g of triethanolamine.

[0073] The preparation process of the total flavonoids of Populus tomentosa leaves for pressure sore cream comprises the following steps:

[0074] SB1. Preparation of total flavonoids from Populus tomentosa leaves;

[0075] SB2. Weigh the water phase and the oil phase matrix respectively, mix them for later use; weigh 0.1g triethanolamine and 0....

Embodiment 3

[0105] On the basis of Example 2, the pressure sore-removing pharmacodynamic experiment was carried out on the Populus tomentosa leaf total flavonoids cream obtained in Example 2 for removing pressure sores.

[0106] 1 Experimental materials

[0107] 1.1 Reagents and drugs

[0108] 1.1.1 Reagents

[0109] Chloral Hydrate; Sodium Sulfide.

[0110] 1.1.2 Drugs

[0111] 0.5% medical iodophor disinfectant, Shandong Lierkang Medical Technology Co., Ltd., registration certificate number: Lu Wei Xiao Zheng Zi (2002) No. 0059, batch number: 20140105; Populus tomentosa leaf total flavonoids cream for pressure sores, experiment Homemade, batch number: 20171112; Jingwanhong ointment; Tianjin Darentang Jingwanhong Pharmaceutical Co., Ltd., approval number: Z12020440, batch number: 212021.

[0112] 1.2 Experimental animals

[0113] 30 ICR mice, half male and half female, weighing 25-30 g, were provided by the Animal Experiment Center of Ningxia Medical University, Animal Production Li...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to pressure sore removing cream prepared from total flavonoids of populus tomentosa leaf and a preparation process of the pressure sore removing cream. The flavonoids in the populus tomentosa leaf are subjected to heating reflux extraction with 70% ethanol, further separation and purification areperformed with D101 macroporous resin and polyamide resin, the total flavonoids of the populus tomentosa leaf are obtained, and the cream is prepared from the total flavonoids of the populus tomentosaleaf. The cream is prepared from the total flavonoids of the populus tomentosa leaf and cream base in parts by weight as follows by mixed processing: 0.4-10.0 parts of the total flavonoids of the populus tomentosa leaf, 5.0-45.0 parts of water, 0.42-3.75 parts of glycerin, 0.94-8.43 parts of stearic acid, 0.08-0.75 parts of vaseline, 0.42-3.75 parts of lanolin, 0.44-3.98 parts of liquid paraffin,0.30-2.70 parts of glyceryl monostearate and 0.1-0.9 parts of triethanolamine stearate soap. The cream has good treatment effect on pressure sores.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to an external cream for treating trauma, in particular to a cream of Populus tomentosa leaves for removing pressure sores and a preparation process thereof. Background technique [0002] Pressure sores are long-term bedridden patients. Due to extreme physical weakness, loss of sensory and motor functions, inability to change lying positions, and improper care, the skin tissue and even muscles located between the bony prominence on the body surface and the mattress may suffer from continuous pressure. , local hypoxia, vascular embolism, ulcers formed by tissue necrosis and decay. Its formation process is divided into three stages: erythema stage, vesicular stage and ulcer stage. The incidence of pressure sores is as high as 1-4.7%, which has become a major problem in clinical nursing work. According to relevant literature, about 60,000 people die of pressure sor...

Claims

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Application Information

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IPC IPC(8): A61K36/76A61K9/06A61P17/02A61P31/02A61P31/04A61K127/00
CPCA61K9/0014A61K9/06A61K36/76A61K47/44A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 付雪艳郭东燕黄俊张义伟董琳高清菡张新慧赵云生
Owner NINGXIA MEDICAL UNIV
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