Detecting method for insoluble particles

Abstract

The invention provides a detecting method for insoluble particles. The method comprises the steps that 1, a needed amount of purified water is taken and filtered through a filter membrane several times, and the filtered purified water is collected and adopted as water for inspecting insoluble particles; 2, the water obtained in step 1 is used for washing a black filter membrane, and no obvious insoluble particles with the size being 5 micrometers or above exist on the filter membrane; 3, the sample is washed with water obtained in step 1, and a washing solution is collected; the washing solution is filtered through the black filter membrane washed in step 2; 4, the black filter membrane used in step 3 is placed under a large-view microscope for counting. According to the detecting method for insoluble particles, the black background filter membrane is adopted, the insoluble particles are easier to judge, light reflection is reduced, and eye fatigue is lowered. According to the method,the filter membrane made of mixed cellulose ester materials is adopted, after the insoluble particles are left on the membrane, blots can be formed, and the detecting accuracy is improved.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for detecting insoluble particles. Background technique [0002] Since medical agents, medical equipment or medical devices cannot be guaranteed to be absolutely dust-free during the production process, when injections, medical devices, etc. enter the blood, dust, particles, etc. may enter the blood circulation system. Insoluble particles enter the human circulatory system and have the potential danger of causing blood clotting and thrombus. Therefore, it is necessary to detect the content of insoluble particles in products that enter the circulatory system and come into contact with blood. The traditional microscopic counting method for detecting insoluble particles uses an ordinary white filter membrane, which is difficult to judge when observing transparent or white insoluble particles, and the white reflection will increase eye fatigue and reduce efficiency. After...

AI Technical Summary

Problems solved by technology

The traditional microscope counting method for detecting insoluble particles uses ordinary white filter membranes, which is difficult to judge when observing transparent or white insoluble particles, and white reflections will increase eye fatigue and reduce efficiency

Particles are easy to lose and move after filtration, causing counting errors

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