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A quantification method for the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement

An equivalent and molecular technology, applied in the field of quantification of the bitterness of multi-ingredient traditional Chinese medicine, achieves significant economic and social benefits and improves the effect of taking

Active Publication Date: 2020-06-30
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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Problems solved by technology

[0003] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a method for quantifying the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement, which can effectively solve the problem of measuring the bitterness of multi-component traditional Chinese medicine, thereby being more accurate and objective Quantitatively compare the bitterness of different drugs and the problem of drug taste masking

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  • A quantification method for the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement
  • A quantification method for the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement
  • A quantification method for the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement

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Embodiment Construction

[0013] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0014] When the present invention is implemented, a method for quantifying the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement comprises the following steps:

[0015] (1), the preparation of bitter Chinese medicinal decoction: take the decoction pieces of the medicinal materials to be tested, add 2000mL of water to 10 times the average value of the weight range (as the amount of Phellodendron cortex is 6-9g, then get 7.5g) according to the pharmacopoeia, add 2000mL of water, soak for 30min, Heat on an induction cooker with a power of 2100W. After boiling, change the power to 600W, decoct for 20 minutes, filter to obtain the filter residue and the first filtrate, add 2000 mL of water to the filter residue, heat, boil and decoct for 10 minutes, filter to obtain the second filtrate, ...

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Abstract

The invention aims to provide a quantifying method for bitter degree of a multi-component traditional Chinese medicine based on molecule bitter degree equivalent measurement; the quantifying method can effectively measure bitter degree of the multi-component traditional Chinese medicine, so that bitter degrees of different medicines as well as the medicine bitter taste masking problem are quantified and compared more accurately and objectively; a minimum limit method is adopted, bitterness threshold (BT) concentrations, namely lowest concentration tasted by half of volunteers, of water solutions of standard bitter substances and bitter-taste traditional Chinese medicine decoction pieces at 37 DEG C are measured; any standard bitter-taste substance is set, molecular bitter degree equivalentof a to-be-measured medicine is calculated according to a formula of EMBs equal to (Cr / Cs)*EMBr. The quantifying method can measure bitter degrees of bitter tastes of medicines, obtains accurate andobjective measured results, provides quantifying indexes for bitter degree evaluation of the medicines, provides technical support for medicine bitter-taste masking, develops a commercial value of themedicines, improves the taking effect of the medicines, and has remarkable economic and social benefits.

Description

technical field [0001] The invention relates to medicine, in particular to a method for quantifying the bitterness of multi-component traditional Chinese medicine based on molecular bitterness equivalent measurement. Background technique [0002] There is an important problem in the current use of traditional Chinese medicine, that is, how to realize the measurement of the bitterness of traditional Chinese medicine, and find a suitable taste-masking agent based on the measured bitterness intensity, so as to improve the compliance of patients taking medicine; , with a variety of flavors, among which bitterness is the most unacceptable. However, its method for quantifying bitterness is different from that of monomeric bitter compounds. A multi-component traditional Chinese medicine bitterness quantification method based on the molecular bitterness equivalent measurement provides a quantitative index for the evaluation of the bitterness of the medicine, and lays the foundation ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15
CPCG01N33/0001G01N33/15
Inventor 刘瑞新李学林姚静桂新景王青晓施钧瀚高晓洁田亮玉康欢
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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