A construction method and application of psoriasis guinea pig blood heat syndrome ear psoriasis disease model

Abstract

The invention relates to the field of animal models, in particular to a construction method and application of a human psoriasis guinea pig blood-heat syndrome ear psoriasis guinea disease model. Theconstruction method comprises the following steps: a, selecting a healthy model guinea pig, and giving compound hot liquid medicine decocta through guinea pig intragastric administration, thus obtaining a blood-heat syndrome guinea pig model in four consecutive weeks; b: respectively smearing propranolol emulsion to two ears of the blood-heat syndrome guinea pig model obtained in step a in three consecutive weeks, thus obtaining the human psoriasis guinea pig blood-heat syndrome ear psoriasis guinea disease model. According to the construction method provided by the invention, the characteristic that a pure syndrome model and a Western medicine pathogenesis pathological model are relatively single is changed, information which is more than pure syndrome or disease models can be provided, and the change of typical psoriasis vulgaris is present in the ear of the guinea pig; an experiment animal model is provided for the syndrome differentiation and treatment of diseases, traditional Chinese medicine treatment determination based on syndrome differentiation and a new medicine pharmacology experiment can adopt corresponding animal models, the practical defect that psoriasis syndrome iscombined with animal models is avoided, the progress of traditional Chinese medicine disease syndrome research and new medicine development are accelerated, and technical service is provided for medicine evaluation.

Description

technical field [0001] The invention relates to the technical field of animal models, in particular to a construction method and application of a psoriasis guinea pig ear psoriasis disease model of blood heat syndrome. Background technique [0002] Psoriasis is a common erythematous, scaly, chronic inflammatory and proliferative skin disease with a high incidence rate, recurrent outbreaks, and difficult to treat. Traditional Chinese medicine is called "white boils, loose skin tinea". The prevalence rate in the natural population is about 1% to 3%. Clinically, psoriasis vulgaris is the most common, and its incidence rate accounts for about 95% of psoriasis. The initial stage is red papules or maculopapules, which gradually expand or merge later. In flakes, bright red or deep red, higher than the skin, with obvious infiltration at the bottom, clear edges, inflammatory flushes around, and multiple layers of off-white or silver-white scales on the surface. [0003] Traditional ...

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Problems solved by technology

[0007] The present invention aims to solve the problem that the existing psoriasis models lack the characteristics of vulgar psoriasis heat syndrome. The existing psoriasis models only focus on the improvement of a certain symptom, and the evaluation index is relatively single, without considering the integrity. Syndrome model and western medicine pathological model are difficult to apply and reflect the technical problems of syndrome characteristics of traditional Chinese medicine, providing a construction method and application of psoriasis guinea pig blood heat syndrome ear psoriasis disease model

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