Acoustic surface wave sorting chip undergoing special wettability optimization

Abstract

The invention discloses an acoustic surface wave sorting chip undergoing special wettability optimization. According to the chip, through fusion of some characteristics of wettability optimization, abroadband / variable frequency interdigital transducer technique and hydraulic sorting and an acoustic surface wave sorting method, cell / particle high-flux enrichment and specific cell / particle high-purity sorting are achieved. During working of the chip, effects of a sound field and acoustic radiation force are achieved on fluid and cells / particles in a micro-channel through acoustic surface wave which is generated by an interdigital transducer. Therefore, by implementing special wettability optimization treatment on the base of a sorting channel, differences in surface tension, adhesive force,shear force, wall slippage and the like can be caused in various wettability micro-area interfaces. Cells, which pass through a sorting area in a lined-up form, can deviate away from an original streamline trajectory under actions of an acoustic streaming effect, the acoustic radiation force, the adhesive force (Stokes force) and the like; and through a coupling effect of the special wettabilityoptimization base, deviation speed and distance of the cells / particles is increased, and a sorting flux and efficiency are improved.

Description

Technical field: [0001] The invention relates to a surface acoustic wave sorting chip, in particular to a novel surface acoustic wave sorting chip with optimized special wettability. Background technique: [0002] Surface wettability is one of the important characteristics of a solid surface, and the contact angle (CA) is usually used to characterize the wettability of a liquid to a solid. Generally speaking, when the contact angle between a solid surface and water is greater than 90°, it is called a hydrophobic surface; when it is less than 90°, it is called a hydrophilic surface. When the contact angle is greater than 150° or close to 0°, these two extreme wettability surfaces are called superhydrophobic and superhydrophilic surfaces. Special wetting surfaces include three types: superhydrophilic / superhydrophobic reversible transition, superhydrophilic-superhydrophobic patterned surfaces, and gradient wetting surfaces. Special wetting surfaces have great application pros...

AI Technical Summary

Problems solved by technology

The existing passive sorting technology generally has high throughput but low sorting precision, while active sorting technology generally has high sorting precision but low throughput

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