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A kind of pharmaceutical composition and its preparation method and application

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, hydroxyl compound active ingredient, etc., can solve the problems of granuloma-like lesions, the safety needs to be investigated, and the waste of drugs, etc., to promote the growth of granulation tissue, facilitate long-term Preserving and promoting the effect of wound repair

Active Publication Date: 2021-06-25
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although western medicine treatment has a single component, the dosage is accurate
However, antibiotics are prone to drug resistance, and the cost of treatment is generally high, and the operation of new technologies is highly professional, so the actual clinical application and promotion in China is not ideal.
[0005] Turtle shell powder is one of the effective prescriptions in the traditional Chinese medicine powder. This prescription uses turtle shell together with coptis, red powder and borneol, etc., and is applied externally to the affected area. It has the effects of detoxifying, promoting blood circulation and relieving pain. The effect is good for sores and other diseases, but the powder has disadvantages such as slow absorption, unabsorbable particles, and even aggravated inflammatory reactions, inducing granuloma-like lesions, inconvenient use, waste of drugs, easy moisture absorption and deterioration, and inconvenient storage. Traditional Chinese medicine generally has complex prescriptions, lack of mechanism research, and safety to be investigated, all of which limit its clinical promotion and application

Method used

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  • A kind of pharmaceutical composition and its preparation method and application
  • A kind of pharmaceutical composition and its preparation method and application
  • A kind of pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] An embodiment of the pharmaceutical composition of the present invention comprises sterol myristate, berberine and borneol, wherein the concentration of sterol myristate is 1.0 mg / ml, and the concentration of berberine is 3 mg / ml, The concentration of borneol is 0.3mg / ml.

[0057] A kind of embodiment of spray film agent of the present invention, comprises above-mentioned pharmaceutical composition and film-forming auxiliary material, and film-forming auxiliary material comprises hydroxypropyl methylcellulose, polyvinylpyrrolidone and alcohol, wherein, the hydroxypropyl methylcellulose The concentration is 0.4% (v / v), the concentration of polyvinylpyrrolidone is 8% (v / v) and alcohol 20% (v / v).

[0058] The preparation method of above-mentioned film-spraying agent, comprises the steps:

[0059] 1) Add 2.1ml Tween 80 dropwise on sterol myristate, mix well, add distilled water, stir until completely dissolved, and obtain a solution of sterol myristate;

[0060] 2) Add bo...

Embodiment 2

[0063] An embodiment of the pharmaceutical composition of the present invention comprises sterol myristate, berberine and d-borneol, wherein the concentration of sterol myristate is 1.2 mg / ml, and the concentration of berberine is 2.5 mg / ml. mg / ml, the concentration of D-borneol is 0.7mg / ml.

[0064] A kind of embodiment of spray film agent of the present invention, comprises above-mentioned pharmaceutical composition and film-forming auxiliary material, and film-forming auxiliary material comprises hydroxypropyl methylcellulose, polyvinylpyrrolidone and alcohol, wherein, the hydroxypropyl methylcellulose The concentration is 0.5% (v / v), the concentration of polyvinylpyrrolidone is 7% (v / v) and alcohol 25% (v / v).

[0065] The preparation method of above-mentioned film-spraying agent, comprises the steps:

[0066] 1) Add 1.9ml Tween 80 dropwise on sterol myristate, mix well, add distilled water, stir until completely dissolved, and obtain a solution of sterol myristate;

[00...

Embodiment 3

[0070] An embodiment of the pharmaceutical composition of the present invention comprises sterol myristate, berberine and borneol, wherein the concentration of sterol myristate is 1.5 mg / ml, and the concentration of berberine is 2 mg / ml, The concentration of borneol is 1 mg / ml.

[0071] A kind of embodiment of spray film agent of the present invention, comprises above-mentioned pharmaceutical composition and film-forming auxiliary material, and film-forming auxiliary material comprises hydroxypropyl methylcellulose, polyvinylpyrrolidone and alcohol, wherein, the hydroxypropyl methylcellulose The concentration is 0.4% (v / v), the concentration of polyvinylpyrrolidone is 6% (v / v) and alcohol 30% (v / v).

[0072] The preparation method of above-mentioned film-spraying agent, comprises the steps:

[0073] 1) Add 2ml Tween 80 dropwise on sterol myristate, mix well, add distilled water, stir until completely dissolved, and obtain a solution of sterol myristate;

[0074] 2) Add borne...

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PUM

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Abstract

The invention discloses a pharmaceutical composition, which includes sterol myristate, berberine and d-borneol or borneol; the invention also discloses a film-spray agent for treating pressure sores and a preparation method thereof. The film-spraying agent comprises the above-mentioned pharmaceutical composition; the film-spraying agent of the present invention is sprayed on the skin to form a film, and the wet environment under the film can effectively isolate bacteria, promote the growth of granulation tissue, and promote wound repair. The film-spraying agent of the present invention The effective rate of treating early-stage pressure sores with the agent is more than 95%; moreover, the film-spray agent of the present invention has minimal toxic and side effects and is very convenient to use.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine or medicinal chemistry, in particular to a pharmaceutical composition capable of treating pressure sores, a film-spraying agent and a preparation method thereof. Background technique [0002] A pressure sore (Prssure Ulcer, PU) is a localized injury to the skin, subcutaneous tissue, or muscle due to the combined action of pressure, shear force, or friction [1]. Traditional Chinese medicine calls pressure sores "seat sores". Once pressure sores occur, they will not heal for a long time, and even endanger the lives of patients in severe cases [2]. Huge pain and economic burden, its high morbidity and difficult to control have long been a difficult problem that plagues medical treatment and nursing. [0003] At present, the treatment of pressure sores by western medicine mainly includes drug treatment, dressing treatment, closed negative pressure drainage technology (VSD technol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K31/4375A61K31/045A61K9/70A61K47/38A61P17/02
CPCA61K9/7015A61K31/045A61K31/4375A61K31/575A61K47/38A61P17/02A61K2300/00
Inventor 李春李瑜黎晖陈东风李伊为梁洁梅余洁仪
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE