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Tumor metastasis inhibitor of targeted mouse platelet membrane glycoprotein GPIb alpha and identification method of inhibitor

A technology of tumor metastasis and membrane glycoprotein, applied in the field of pharmacology, tumor metastasis inhibitor targeting mouse platelet membrane glycoprotein GPIbα and its identification, can solve the problems such as the unclear role of GPIbα, so as to facilitate research and inhibit tumor transfer effect

Inactive Publication Date: 2018-07-31
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few published studies on the role of platelet-targeted GPIbα monoclonal antibodies in the process of tumor metastasis, and the role of GPIbα in the process of tumor metastasis is still unclear

Method used

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  • Tumor metastasis inhibitor of targeted mouse platelet membrane glycoprotein GPIb alpha and identification method of inhibitor
  • Tumor metastasis inhibitor of targeted mouse platelet membrane glycoprotein GPIb alpha and identification method of inhibitor
  • Tumor metastasis inhibitor of targeted mouse platelet membrane glycoprotein GPIb alpha and identification method of inhibitor

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Embodiment Construction

[0027] Below in conjunction with specific embodiment, further illustrate the present invention. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

[0028] In order to understand the technical content of the present invention more clearly, the following examples are given in detail.

[0029] Targeting mouse platelet GPIbα tumor met...

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Abstract

The invention relates to a tumor metastasis inhibitor of a targeted mouse platelet membrane glycoprotein GPIb alpha. The tumor metastasis inhibitor is a monoclonal antibody 1D12 or 2B4. The inventionfurther relates to an identification method of the tumor metastasis inhibitor of the targeted mouse platelet membrane glycoprotein GPIb alpha. The targeting performance and functionality of the inhibitor are verified by establishing verification models of the tumor metastasis inhibitor of the targeted mouse platelet membrane glycoprotein GPIb alpha. Through verification of the four verification models, it is determined that the targeted mouse platelet GPIb alpha monoclonal antibody 1D12 or 2B4 can effectively inhibit tumor cell metastasis and does not influence normal platelet functions. The possibility is provided for the research of the specific action mechanism of GPIb alpha in the tumor metastasis process.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to pharmacology, and specifically refers to a tumor metastasis inhibitor targeting mouse platelet membrane glycoprotein GPIbα and an identification method thereof. Background technique [0002] Platelets can promote tumor metastasis, and the first and key point in promoting tumor metastasis is the activation of platelets by tumor cells to form tumor thrombi. Various adhesion molecules on the surface of platelets, such as glycoprotein (Glycoprotein, GP) Ib-IX-V, GPIIb-IIIa, etc., interact to mediate the adhesion of tumor cells to platelets. Among them, GPIbα is the largest and most important component of the GPIb-IX-V complex. Studies have shown that knocking out the GPIbα gene or replacing the GPIbα extracellular region in mouse models can significantly reduce the lung metastasis of lung cancer in mice, but it will be complicated by thrombocytopenia (Jain S, Zuka M, Liu J, et al.Proc N...

Claims

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Application Information

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IPC IPC(8): C07K16/28G01N33/68G01N33/577C12Q1/02
CPCC07K16/2896C12N2503/02G01N33/5011G01N33/577G01N33/6854G01N2333/70596G01N2500/10
Inventor 梁欣刘建文亓莹雪
Owner EAST CHINA UNIV OF SCI & TECH
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