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Extraction and purification technique of antiviral drug

A technology of antiviral drugs and technology, applied in the field of biomedicine, can solve the problems of lack of specific anti-HIV drugs

Inactive Publication Date: 2018-08-10
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before 2002, there was a lack of specific anti-HIV drugs in China. According to the theory of traditional Chinese medicine, traditional Chinese medicine and western medicine combined disease differentiation and syndrome differentiation for AIDS patients in clinical practice. , according to the performance of traditional Chinese medicine, select traditional Chinese medicine, prescription treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Extraction and purification of antiviral drugs in the formula of Kidney Leaf Dawanhua, White Bud Capsule, and Hollyhock Flower

[0026] (1) Take 5 parts by weight of kidney leaf dawanhua, 8 parts by weight of white bud capsule, and 1 part by weight of hollyhock flower, mix well and pulverize into coarse powder, extract 3 times with 70% ethanol as solvent, and extract 4 parts by soaking at room temperature each time. hour, the amount of 70% ethanol is 12 times of the total weight of medicinal materials, filters, and merges the filtrate to obtain extract A; the dregs after extraction are extracted 2 times with 30% ethanol as a solvent, and each heating and reflux extracts for 1.5 hours, 30% The amount of ethanol is 10 times of the total weight of the medicinal materials, filtered, and the filtrates are combined to obtain the extract B; the extracted medicinal residues are then heated with water as the solvent to reflux for extraction for 1.5 hours, filtered, and...

Embodiment 2

[0035] Example 2: Extraction and purification of antiviral drugs in the formula of Kidney Leaf Dawanhua, White Bud Capsule, and Hollyhock Flower

[0036] (1) Take 20 parts by weight of kidney leaf Dawan flower, 7 parts by weight of white bud capsule, and 5 parts by weight of hollyhock flower, mix and pulverize into a coarse powder, use 70% ethanol as solvent to extract 3 times, soak and extract 4 parts at room temperature each time hour, the amount of 70% ethanol is 12 times of the total weight of medicinal materials, filters, and merges the filtrate to obtain extract A; the dregs after extraction are extracted 2 times with 30% ethanol as a solvent, and each heating and reflux extracts for 1.5 hours, 30% The amount of ethanol is 10 times of the total weight of the medicinal materials, filtered, and the filtrates are combined to obtain the extract B; the extracted medicinal residues are then heated with water as the solvent to reflux for extraction for 1.5 hours, filtered, and t...

Embodiment 3

[0045] Example 3: Extraction and purification of antiviral drugs in the formula of Kidney Leaf Dawanhua, White Bud Capsule, and Hollyhock Flower

[0046] (1) Take 3 parts by weight of kidney leaf Dawanhua, 8 parts by weight of white bud capsule, and 5 parts by weight of hollyhock flower, mix well and pulverize into a coarse powder, extract 3 times with 70% ethanol as a solvent, and extract 4 parts by soaking at room temperature each time. hour, the amount of 70% ethanol is 12 times of the total weight of medicinal materials, filters, and merges the filtrate to obtain extract A; the dregs after extraction are extracted 2 times with 30% ethanol as a solvent, and each heating and reflux extracts for 1.5 hours, 30% The amount of ethanol is 10 times of the total weight of the medicinal materials, filtered, and the filtrates are combined to obtain the extract B; the extracted medicinal residues are then heated with water as the solvent to reflux for extraction for 1.5 hours, filtered...

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PUM

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Abstract

The technical scheme discloses an extraction and purification technique of an antiviral drug. The antiviral drug is prepared by: subjecting Calystegia soldanella, Gymnotheca involucrata and Abelmoschus manihot as materials to extraction, isolating, and purifying to obtain the antiviral drug composed of calystegin V, calystegin VI, calystegin VIII, calystegin IX, calystegin XII, Gymnotheca lignin A, and isoquercitrin.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to an extraction and purification technology of antiviral drugs, in particular to an extraction and purification technology of antiviral drugs in a formula composed of kidney leaf dawanhua, white bud capsule and marshmallow flower. Background technique [0002] Traditional Chinese medicine comes from plants, animals, and minerals, and is an important part of medicine. As early as the early Shang Dynasty, people extracted and prepared effective parts from traditional Chinese medicines for disease prevention and treatment, such as oral administration or external application of traditional Chinese medicine decoction; the Ming Dynasty "Compendium of Materia Medica" recorded in detail the process of preparing and purifying camphor by sublimation method; "Bai Yuan Ji" describes the method of extracting and separating crystalline aconitine from fresh Aconitum aconitum; "Introduction to Medicine" re...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P31/12
CPCA61K36/185A61K36/39A61K36/78A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P31/12A61K2300/00
Inventor 李静超
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD