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Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2

A single nucleotide polymorphism, DP-2 technology, applied in hair care, grooming preparations, medical preparations containing active ingredients, etc., can solve the problem that the active target of minoxidil has not been determined

Inactive Publication Date: 2018-08-31
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Active target of minoxidil in AGA treatment has not been identified

Method used

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  • Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2
  • Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2
  • Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2

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Experimental program
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Embodiment

[0103] CRTH2 / DP-2 antagonists reverse the effect of PGP 2 hair growth inhibition

[0104] Androgenetic alopecia (AGA) is the most common type of hair loss, affecting approximately 50% of men and 30% of women before the age of 50. Apart from testosterone being necessary for the development of AGA in men, other contributing factors remain unknown. Blocking the conversion of testosterone to its more potent form, dihydrotestosterone, by administering the drug finasteride (Propecia) benefited early-stage AGA patients, but did not completely reverse hair miniaturization. This suggests that the development of more effective treatments depends on identifying other factors that also contribute to the development of AGA.

[0105] To achieve this goal, we previously used a global gene expression approach to discover differentially expressed genes in bald versus non-bald scalp from the same individual (Garza et al. (2012) Sci. Transl. Med. 4, 126ra34). Prostaglandin D 2 Synthase (PTGD...

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Abstract

DP-2 antagonists reversed PGD2-mediated human hair growth inhibition in a dose-dependent manner in vitro by reducing PGD2-triggered apoptosis and maintaining proliferation of keratinocytes. Hair follicles from approximately half of the alopecia patients exhibited little susceptibility to PGD2's effect in vitro. SNPs in the human DP-2 gene were identified that are associated with hair growth inhibition by PGD2. These findings underscore the role of DP-2 in regulating hair growth and indicate that DP-2 can be an effective approach in preventing and / or treating androgenetic alopecia in patients sensitive to PGD2. Furthermore, the SNPs identified here can be used to identify patients who will benefit from treatment.

Description

technical field [0001] The present invention relates to compositions and methods for regulating hair growth. In particular, the invention relates to identifying subjects such as those with androgenetic alopecia or alopecia or hair loss that are responsive to prostaglandin D2 (PGD 2 ) are susceptible to hair growth inhibition and respond to PGD 2 Receptor, DP-2 (aka CRTH2 or GPR44) antagonists to stimulate hair growth. Background technique [0002] Eighty percent of Caucasian men experience some degree of androgenetic alopecia (AGA) before the age of 70. Testosterone is essential for the development of AGA, and a genetic predisposition locus in the androgen receptor is present in a small number of men with AGA; however, other factors responsible for the disease remain unknown. Research on AGA has the potential to inform other androgen-mediated diseases, such as benign prostatic hypertrophy and prostate cancer. Current legal treatments for AGA include finasteride, minoxidi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q7/00A61P17/00A61P17/14A61K38/57
CPCA61Q7/00A61K38/00A61K8/368A61K8/492A61K8/4926A61K8/69A61K2800/92C12Q1/68C12Q1/6883C12Q2600/106C12Q2600/156A61K31/473A61K31/506A61P17/00A61P17/14A61P43/00A61K9/0014A61K9/0053A61K31/192A61K31/404A61K31/437A61K31/47
Inventor G·科特萨雷利斯Y·郑J-C·谢J·欧布赖恩D·W·科林斯
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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