Low intensity pulsed ultrasound activated neuron imaging device and operation method
A low-frequency pulse and imaging device technology, applied in the field of medical engineering, can solve problems such as undefined low-frequency energy and time window action thresholds, unexplained nervous system functions, etc., to ensure integrity, good research, and ensure the effect of survival rate
Inactive Publication Date: 2018-09-28
THE THIRD AFFILIATED HOSPITAL INST OF FIELD SURGERY OF PLA ARMY MEDICAL UNIV
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Problems solved by technology
However, its further neurological effects have not been elucidated, mainly because researchers have not yet defined the threshold of action of low-frequency energy and time window in target tissues and target cells
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[0020] Embodiments of the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and therefore are only examples, rather than limiting the protection scope of the present invention.
[0021] Such as figure 1 As shown, the present invention discloses an imaging device for activating neurons by low-frequency pulsed ultrasound (Low intensity pulsed ultrasound), comprising a low-frequency pulsed ultrasound exciter 1, a stage 2 and a microscope 3; the low-frequency pulsed ultrasound exciter 1 is arranged on an object Above the platform 2, the microscope 3 is arranged under the stage 2; the stage 2 is used to place the culture dish 4 equipped with neurons; the low-frequency pulse ultrasonic exciter 1 is used to emit neurons in the culture dish Low-frequency pulsed ultrasonic waves mechanically stimul...
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Abstract
The invention discloses a low intensity pulsed ultrasound activated neuron imaging device and an operation method. The imaging device comprises a low intensity pulsed ultrasound exciter, an objectivetable and a microscope, wherein the low intensity pulsed ultrasound exciter is arranged above the objective table; the microscope is arranged under the objective table; the objective table is used forplacing a culture dish filled with neurons; the low intensity pulsed ultrasound exciter is used for emitting low intensity pulsed ultrasound waves into the neurons in the culture dish to perform mechanical stimulation on the neurons for generating the activation or inhibition biological effect; the microscope is used for emitting laser to the neurons in the culture dish, and the neurons in the culture dish are observed through refracted scattered light. The integrity and the survival rate of the neurons are ensured, so that the neurons can be better studied.
Description
technical field [0001] The invention relates to the technical field of medical engineering, in particular to an imaging device and an operation method for activating neurons by low-frequency pulsed ultrasound. Background technique [0002] The human visual pathway nervous system is the pathway of visual transmission. From the optic nerve, through the optic chiasm, optic tract, lateral geniculate body, and optic radiation to the cortical optic center. After the nerve cells on the retina are stimulated by light, they generate nerve impulses, which are transmitted to the visual center in the brain through the nervous system. Optic nerve damage or persistent high intraocular pressure can lead to massive death of retinal ganglion cells. At present, "optogenetics", deep brain stimulation and non-invasive "magnetogenetics" are usually used. Optogenetics and deep brain stimulation require implantation of optical fibers or metal electrodes in the brain, which will cause direct dama...
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Login to View More IPC IPC(8): G01N29/02
CPCG01N29/022G01N2291/022
Inventor 林森叶剑周家兴刘蕴佳
Owner THE THIRD AFFILIATED HOSPITAL INST OF FIELD SURGERY OF PLA ARMY MEDICAL UNIV